40 Legionella and Coxiella belong to the same family of bacteria, and both are associated with a syndrome of long-lasting post-infectious fatigue. These bacteria are under-reported in most parts of the world. However, as they are usually susceptible to macrolides/azalides, tetracyclines...
Infection in immunocompetent mice appears to be self-limiting, lasting up to several weeks but terminating with the development of host immunity. Nevertheless, the presence of a carrier state has not been excluded. The course of infection in immunodeficient mice should be considered prolonged, but...
Though the AdC68-G vaccine of the study is a replication-deficient virus, it can still induce a durable (68 weeks) immune response in mice, which is consistent with other study30. While the exact mechanism behind the long-lasting and sustained immune responses is currently unknown31. The ...
Strikingly, all animals again became infected, with incubation times of 2–3 days and viraemia lasting 5–6 days. At 4 and 5 days p.i., body temperature in all pigs was above 39.5 °C (Fig. 4d). Again, as early as 3 days p.i., some pigs had viral RNA- positive oronasal swabs...
Complete, Long-Lasting Protection against Lethal Infectious Bursal Disease Virus Challenge by a Single Vaccination with an Avian Herpesvirus Vector Express... Marek's disease herpesvirus is a vaccine vector of great promise for chickens; however, complete protection against foreign infectious diseases has...
Unexpectedly, we found that the virulence of our rLong-ΔG strain was less than 1 log attenuated in the lung of Balb/c mice on day 3, indicating that the rLong-ΔG virus was not over-attenuated. Thus, this newly constructed ΔG virus may be less attenuated than previously described Δ...
In a phase 1 clinical trial, the evaluation of the safety and immunogenicity of DS-Cav1 in healthy adults aged 18-50 years showed that it was safe and induced strong RSV F-specific antibodies and neutralizing activity lasting more than 44 weeks (NCT03049488) [106]. GlaxoSmithKline has ...
This invention shows that HAV can be isolated and serially propagated in AGMK cell culture taken directly from human specimens. The virus isolated from stool experienced an eclipse phase lasting approximately 4 weeks, after which the amount of HA Ag increased. The serial passage of HM-175 substan...
lasting for a week or less. The second type of clinical picture is associated with a sudden onset of clinical signs in naive postweanling-to-adult rats that have been exposed to infected rats. Signs include cervicalswelling due to inflammation and edema ofsubmaxillary salivary glands(Fig. 9),...
horizontal transmission. An alternative infection strategy would be that HgNV persists as a latent virus within the host and its evolution has favoured the maintenance of low virulence, which subsequently translates to an increase in transmission through longer lasting infections, as infection doesn’t...