5 CD4+ T-cell counts may be altered by SJS/TEN. Roujeau et al8 showed that CD4+ T-cell counts decreased in patients with TEN. Azukizawa demonstrated that in vivo deletion of CD4+ T cells induced TEN in transgenic mice.9 However, Nishio et al10 showed no statistically significant changes...
West Nile virus (WNV) replicates in the skin; however, cell targets in the skin have not been identified. In the current studies, WNV infected the epidermis and adnexal glands of mouse skin, and the epidermal cells were identified as keratinocytes by double labeling for WNV antigen and keratin...
To gain deeper insights into the molecular pathogenesis of HIV/SIV induced oral mucosal dysfunction and its modulation by THC, we performed RNA-seq of OPM samples collected at necropsy. Relative to uninfected controls, 461 genes were found to be significantly upregulated and differentially expressed...
Additionally, several IFN-induced miRNAs (miR-196, miR-296, miR-351, miR- Int. J. Mol. Sci. 2018, 19, 3381 13 of 19 reportedly promote viral replication, including miR-122, which promotes HCV RNA accumulation by binding to HCV genomic RNA to stimulate its translation [38]. In the ...