In alysogenic cycle, the phage genome also enters the cell through attachment and penetration. A prime example of a phage with this type of life cycle is the lambda phage. During the lysogenic cycle, instead of killing the host, the phage genome integrates into the bacterial chromosome and be...
Repressing both HCMV lytic and reactivation phases by epigenetic-targeted therapy, “blocking and locking” the virus HCMV lytic cycle and reactivation from latency are under the control of several epigenetic mechanisms. For example, histone demethylases (HDMs), due to their ability to remove the ...
Repressing both HCMV lytic and reactivation phases by epigenetic-targeted therapy, “blocking and locking” the virus HCMV lytic cycle and reactivation from latency are under the control of several epigenetic mechanisms. For example, histone demethylases (HDMs), due to their ability to remove the ...
The sequential action of these TFs poses a challenge to precisely delineate the contributions of the host and viral phases of the transcriptional program to guide future mechanistic and therapeutic studies. To address this limitation, we devised a genome engineering approach to mutate tat and ...
Herpesviruses are characterized as having two distinct life cycle phases: lytic replication and latency. The mechanisms of latency establishment and mainte... TT Wu,EJ Usherwood,JP Stewart,... - 《Journal of Virology》 被引量: 337发表: 2000年 TLR9 contributes to antiviral immunity during gammaher...
SOs are recruited to the periphery of viral factories (VFs) during late phases of infection and appear to be modified lysosomes. In fact, reovirus infection promotes the modification of lysosome dynamics, morphology, and function. The number and size of lysosomes are increased in reovirus-infected...
a viral kinase involved in HSV nuclear egress [93]. Benedyk et al.reported that these pUS3 mutations reduced stability and kinase activity, suggesting that pUL21 may counteract pUS3 kinase through PP1 recruitment for the same substrates (e.g. pUL31) in the later phases of infection (Fig....
The mechanism of Epstein-Barr Virus-induced Nervous System damage. EBV life cycle has two phases, including latent phase which provided proliferated viruses without immune reactions. When the number of viruses increased, the immune system reacted against viruses. The EBV-infected B-cells activate whi...
KSHV can enter a latent stage in the viral life cycle limiting the expression of viral proteins and immunosurveillance responses, thus allowing persistent infection. The virus infects endothelial cells and B lymphocytes in blood and lymph vessels, and shows dual latent and lytic phases [154]. KSHV...
Once attachment has occurred, the virus must penetrate the cell membrane, and the capsid must undergo a series of disassembly steps (uncoating) that prepare the virus for the next phases in viral replication. Enveloped viruses such as the paramyxoviruses and retroviruses enter cells by fusion of...