In alysogenic cycle, the phage genome also enters the cell through attachment and penetration. A prime example of a phage with this type of life cycle is the lambda phage. During the lysogenic cycle, instead of killing the host, the phage genome integrates into the bacterial chromosome and be...
viral life cycleRISCKaposi's sarcoma-associated herpesvirus (KSHV) is linked with Kaposi's sarcoma and lymphomas. The pathogenesis of KSHV depends on the balance between two phases of the viral cycle: latency and lytic replication. In this study, we report that KSHV-encoded microRNAs (miRNAs) ...
SOs are recruited to the periphery of viral factories (VFs) during late phases of infection and appear to be modified lysosomes. In fact, reovirus infection promotes the modification of lysosome dynamics, morphology, and function. The number and size of lysosomes are increased in reovirus-infected...
The picture emerging from the studies with FMDV and LCMV is that the transition towards viral extinction associated with lethal mutagenesis can have at least two phases: an initial one, with a limited input of mutations in the viral genomes, in which a subset of defective genomes that have bee...
Viral capsids are often regarded as inert structural units, but in actuality they display fascinating dynamics during different stages of their life cycle. With the advent of single-particle approaches and high-resolution techniques, it is now possible to scrutinize viral dynamics during and after th...
a viral kinase involved in HSV nuclear egress [93]. Benedyk et al.reported that these pUS3 mutations reduced stability and kinase activity, suggesting that pUL21 may counteract pUS3 kinase through PP1 recruitment for the same substrates (e.g. pUL31) in the later phases of infection (Fig....
Repressing both HCMV lytic and reactivation phases by epigenetic-targeted therapy, “blocking and locking” the virus HCMV lytic cycle and reactivation from latency are under the control of several epigenetic mechanisms. For example, histone demethylases (HDMs), due to their ability to remove the ...
Completion of a full infectious virus life cycle by uDNA through viral complementation Late gene expression from uDNA begs an important ques- tion: Do virions generated by an integrated provirus pack- age functional genomes derived from uDNA, allowing uDNA to complete its replication cycle and ...
Pharmacological strategies to prevent SARS-CoV-2 infection and treat the early phases of COVID-19 Protein-based vaccines Proteinsubunit vaccinesconsist of a protein purified from the virus or arecombinant protein, generally requiring the addition of an adjuvant to induce a strong immune response. The...
Several viruses use strategies to hijack processes regulated by ubiquitination, during various phases of their life cycle, including during viral entry (Rudnicka and Yamauchi, 2016; Schneider et al., 2021). In respect to virus entry, ubiquitination can also maintain a balance between proviral and...