The shingleback lizards, in which a related virus was detected, were wild caught in western Australia and found to have a disease syndrome called “bobtail flu,” with clinical signs including mucopurulent discharge from the eyes and nose, lethargy, lack of appetite, pale mucous membranes, depres...
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is the cause of coronavirus disease 2019 (COVID-19); a severe respiratory distress that has emerged from the city of Wuhan, Hubei province, China during December 2019. COVID-19 is currently the major global health prob...
Silicon nanowire (SiNW) field-effect transistor (FET) biosensors have already been used as powerful sensors for the direct detection of disease-related bio... Y Zhang,R Chen,L Xu,... - 《Analytical Sciences the International Journal of the Japan Society for Analytical Chemistry》 被引量: 9...
Visceral adiposity is a risk factor for severe COVID-19, and a link between adipose tissue infection and disease progression has been proposed. Here we demonstrate that SARS-CoV-2 infects human adipose tissue and undergoes productive infection in fat cells. However, susceptibility to infection and...
In human subjects, heterozygous carriers of STAT2 null mutations are clinically unaffected; however, those with complete loss of STAT2 function showed the interesting phenotype of severe viral disease from live-attenuated virus vaccines, such as those for measles, mumps, and rubella (MMR) and ...
The researchers hope their open-access tool can be used by other scientists, policymakers and public health officials to prioritize viruses for further study, surveillance and risk-reducing activities, such as possibly developing vaccines or therapeutics before a disease spills over. Thousands of new ...
2002), it quickly emerged as a new therapeutic strategy to suppress the expression of disease-causing gene. So far, the therapeutic potential of siRNA has been demonstrated successfully both in vitro and in vivo (Shim and Kwon 2010) while a number of siRNA-based therapy clinical trials have ...
In some cases, this will facilitate zoonotic spillover—a mechanistic link between global environmental change and disease emergence. Here we simulate potential hotspots of future viral sharing, using a phylogeographical model of the mammal–virus network, and projections of geographical range shifts ...
Thus, for example, there seems to be a direct link between the IL-8 plasma levels of SARS patients and disease severity, similar to what has been described for pulmonary infections caused by respiratory syncytial virus. In contrast, despite the upregulation of IL-8 in intestinal epithelial ...
Insights into the PX (phox-homology) domain and SNX (sorting nexin) protein families: Structures, functions and roles in disease. Biochem. J. 2012, 441, 39–59. [Google Scholar] [CrossRef] Lu, Y.; He, P.; Zhang, Y.; Ren, Y.; Zhang, L. The emerging roles of retromer and ...