5). Specifically, we set astrocytes and microglia as the senders and neurons as the receivers to find signals that cause neuron dysfunctions or neuronal death. Fig. 5 Connection to intracellular risk genes. (A) Connection of astrocyte’s ligand genes to neurons’ risk genes in Alzheimer’s. ...
Gonzales, K. A. U. & Fuchs, E. Skin and its regenerative powers: an alliance between stem cells and their niche. Dev. Cell 43, 387–401 (2017). Article CAS PubMed Google Scholar Hu, S. et al. Needle-free injection of exosomes derived from human dermal fibroblast spheroids ameliorates...
8e). Taken together, these results indicate that co-inhibition of SPHK1 and FLT3 potently inhibits β-catenin and its downstream targets, thereby inducing cell death in FLT3-ITD+ AML cells. Fig. 8 Combined SPHK1 inhibitor and TKI treatment suppresses β-catenin signaling, reducing β-catenin ...
Hepatocellular carcinoma (HCC) is the most prevalent subtype of liver cancer, and it is characterized by high rate of metastasis and recurrence. Recent studies have boosted our understanding that Gankyrin contributes to both of these pathological propert
SE Abiola,R Gonzales,RJ Blendon,... - 《Health Affairs》 被引量: 22发表: 2011年 Survey In Sub-Saharan Africa Shows Substantial Support For Government Efforts To Improve Health Services. Public opinion can play an important role in shaping health policy alternatives and outcomes. However, littl...
1E). Thus, the increased release of inflammatory cytokines in the conditional medium from TCS-activated microglia can induce neuron death. 3.2. TCS induces inflammatory activation in microglia We used NF-κB, a key inflammatory response regulator, to investigate whether TCS increases NF-κB ...
Gonzales, T.-E. Chen, L.S. Conklin, …, X. Li Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBS-induced colitis Inflammatory Bowel Diseases, 15 (2008), pp. 341-352 Google Scholar Andoh et al., 2007 A. Andoh, S. Sakata, Y. Koizumi, K. Mitsuyama,...
Aphid proliferation on plants can cause stunting, severe leaf curling and plant death. Moreover, short probing punctures in cells along the path to the phloem allow the acquisition/transmission of non-persistent viruses [2]. When the stylets reach the phloem, the acquisition/transmission of ...
Cell death was also observed following Cdt2 depletion. Finally, switch-like degradation of p21-GFP at the G1/S transition was abolished when Cdt2 was depleted (Fig. 5a). Thus, our data show that CRL4Cdt2 is essential for degrading p21 during S-phase and is responsible for the switch-...
Congenital heart disease (CHD) is the most common cause of congenital anomaly and a leading cause of morbidity and mortality worldwide. Generation of cardiomyoctyes derived from pluripotent stem cells (PSCs) has opened new avenues for investigation of hu