The aim of the present study was to examine the possible association of the gene expression of VHL, HIF1A, HIF2A, VEGFA and tumor proteinP53 (P53) in cancer tissue with the outcome of ccRCC patients who were treated with sunitinib as firstline therapy following nephrectomy. A total of 36...
Therefore, we demonstrated that downregulation of miR-23b suppressed tumor survival through targeting VHL, leading to the inhibition of β-catenin/Tcf-4 and HIF-1α/VEGF signaling pathways. glioma, HIF-1α, microRNA, VHL, β-catenin Topic: apoptosis polymerase chain reaction vascular ...
【题目】2019年诺贝尔生理和医学奖获得者的研究发现,当正常人处于低氧条件下,缺氧诱导因子(HIF-1α)含量会上升,激活并调节肾脏细胞中促红细胞生成素(EPO)基因的表达,从而使红细胞数量增加以适应低氧环境。EPO还可诱导血管内皮细胞生成因子(VEGF)基因的表达,促进血管的生成。在富氧条件下,HIF-1α被羟基化后与VHL蛋白...
ASSA14-03-23CREG over-expression in BMSC protect against myocardial infarction via VHL/HIF-1α/VEGF pathway mediated vascularisationWe hypothesised that mesenchymal stem cells (MSCs) overexpressing Cellular Repressor of E1A-stimulated Genes (CREG) showed improved survival and engraftment in the ...
Therefore, we demonstrated that downregulation of miR-23b suppressed tumor survival through targeting VHL, leading to the inhibition of β-catenin/Tcf-4 and HIF-1α/VEGF signaling pathways. 展开 关键词: glioma HIF-1α microRNA VHL β-catenin ...
p-VHL/HIF-1 alpha/VEGF signaling pathwaySafflower yellowSafflower yellow (SY) is an active component ofCarthamus tinctorius L. that is widely used in orthopedics. This study aimed to evaluate the role of SY in angiogenesis and osteogenic differentiation.The migration and in vitro angiogenesis of ...
VHL regulates the effects of miR-23b on glioma survival and invasion via suppression of HIF-1伪/VEGF and 尾-catenin/Tcf-4 signaling VHL regulates the effects ofmiR-23b on glioma survival and invasion via suppressionof HIF-1α/VEGF andβ-catenin/Tcf-4 signaling. Chen L,,Han L,... L ...
Regulatory role of vHL/HIF-1 alpha in hypoxia-induced VEGF production in hepatic stellate cells [ J ]. Biochem Biophys Res Commun, 2004, 317 ( 2 ) : 358-362.Wang YQ, Luk JM, Ikeda K, Man K, Chu AC, Kaneda K, Fan ST: Regulatory role of vHL/HIF-1alpha in hypoxia-induced VEGF ...
p-VHL/HIF-1 alpha/VEGF signaling pathwaySafflower yellowObjective: Safflower yellow (SY) is an active component ofCarthamus tinctorius L. that is widely used in orthopedics. This study aimed to evaluate the role of SY in angiogenesis and osteogenic differentiation.Biomedicine & pharmacotherapy =: ...
ebv-circLMP2A is positively correlated with microvessel density, HIF1α, and VEGFA expression in EBVaGC.ebv-circLMP2A promotes tube formation and migration of HUVECs under hypoxia.ebv-circLMP2A promotes hypoxia-induced angiogenesis through KHSRP/VHL/HIF1α/VEGFA axis.HIF1α induces ebv-circLMP...