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Discusses the role of von Hippel-Lindau (VHL) tumor suppressor protein to ubiquitin ligase activity. Tumors where humans are predisposed in the mutation of one germline copy of the VHL gene; Analogies that tie VHL into the ubiquitin system; Interaction of VHL with the proteins ElonginC, Elongin...
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Baba M, Hirai S, Kawakami S, Kishida T, Sakai N, Kaneko S, Yao M, Shuin T, Kubota Y, Hosaka M, et al. Tumor suppressor protein VHL is induced at high cell density and mediates contact inhibition of cell growth. Oncogene. 2001; 20(22):2727-36....
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cellneuroendocrinecarcinomaswithactivatedEGFR/AKT/mTORpathway.Neuroendocrinol.2012;96(3):228-237.国内依维莫司临床试验L2101InhibitionofTORC1andTORC2Complexes35MolecularBasisRAPTORmTORPI3KAKTRTKIntracellularmTORTorc1complex(rapalogsensitive)RICTORTorc2complex(rapaloginsensitive)AdditionaloncogenicfunctionsExtracellular...
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