The von Hippel-Lindau (VHL) tumour suppressor gene is a critical component of the VHL-Cullin2-ElonginB/C (VCB) complex that regulates the ubiquitin-mediated proteasomal degradation of proteins with mutations consistently associated with the development of clear cell renal cell carcinoma (ccRCC). ...
在正常氧气供应下,HIF的α亚基被氧化,随后被PHD羟基化,然后与pVHL结合,pVHL是E3泛素连接酶复合物的一个亚基,能直接与转录延长因子Elongin C连接,再结合Elongin B、CUL2蛋白和环指蛋白RBX1最终形成VCB-CR复合体,该复合体属于E3泛素连接酶系统,可促进HIF-α泛素化并随后在蛋白酶体降解 [ 11 ],从而不会产生EPO。
Together, Elongin B (ELOB) and Elongin C (ELOC) form a heterodimer that serves as the regulatory subunit for the Elongin complex--a general transcription elongation factor that increases RNA Polymerase II transcription through template-encoded arresting sites. The ELOB/ELOC complex also binds to ...
pvhl与elonginb和elonginc蛋白结合而组成pvhl-elonginc-elonginb复合体(vcb),阻断了elonginabc复合体的形成,使mrna聚合酶ⅱ失去有效的激活物而不能激活,导致转录延长过程的终止。(2)介导多种蛋白的降解。pvhl具有α和β两个主要的区域[4],pvhl通过β区域特异性识别和结合底物分子,再通过α区域呈递底物分子,从而起...
ChemicalBook provide Chemical industry users with Recombinant Human Elongin B/Elongin C/VHL Complex, CF Boiling point Melting point,Recombinant Human Elongin B/Elongin C/VHL Complex, CF Density MSDS Formula Use,If You also need to Recombinant Human Elong
VCB binds more weakly to the binary complex BRD9-BD:5 (K d = 73 nM) compared to compound 5 alone (K d = 33 nM), indicating negative cooperativity. To characterize biophysically the interplay between VCB (VHL-ElonginC-ElonginB complex), compound 5, and the BRD9 bromodomain, we applied...
pVHL可与elonginB、elonginC、cullin一 多发肾癌晚期,失去治疗 时机 ,纳入随访。患者 2及Rbxl等其他蛋白结合形成复合物VCB—Cul2, 安徽医科大学学报 ActaUniversitatisMedicinalisAnhui2015May;50(5) ·639 · 碱基 C,发生错义突变,家族3因外显子 1碱基A转 参考文献 换为碱基 G,导致错义突变。但是同一家族之间...
VCB-Cul2 complex ECV complex 背景信息 The VHL complex is a multi-subunit ubiquitin ligase composed of VHL, Elongin B, Elongin C, Cul2 and Rbx1. The VHL protein serves as the substrate recognition component and is linked by Elongin C to a heterodimeric Cul2/Rbx1 module that functions as a...
人VHL/ELONGINB/ELONGINC COMPLEX 复合物, TAG FREE CBNumber: CB813746120 分子式: 分子量: 0 MOL File: Mol file 化学性质安全信息用途供应商1 人VHL/ELONGINB/ELONGINC COMPLEX 复合物, TAG FREE化学性质 安全信息 人VHL/ELONGINB/ELONGINC COMPLEX 复合物, TAG FREE性质、用途与生产工艺 ...
The crystal structure of VH298 bound to the VHL:ElonginB:ElonginC (VBC) complex (Fig. 1b, stereo view inSupplementary Fig. 2) was solved to 2.4 Å resolution (X-ray data collection, processing and refinement statistics are inSupplementary Table 1). VH298 retains the same overall bindin...