Rabbit monoclonal antibody to Vimentin. Recombinant fusion of anti-Vimentin VHH [CTK0211] and rabbit IgG Fc domain.
Mouse monoclonal antibody to GFP. Recombinant fusion of anti-GFP VHH [CTK0201] and mouse IgG1 Fc domain. Host/IsoType Mouse/IgG1 Specificity GFP and GFP derivates Applications IF Conjugate Unconjugated Clone No. CTK0201 Publications 1Cat No : gfms Synonyms GFP, GFP tag, GFP-tag ...
注释:sdAb:single domain antibody,VHH:Variable domain of the heavy chain of heavy‐chain‐only antibody,ADCC:Antibody-dependent cellular cytotoxicity。 1. Shen, Juqun et al. “Single variable domain-IgG fusion. A novel recombinant approach to Fc domain-containing bispecific antibodies.” The Journal...
1993年,比利时布鲁塞尔自由大学免疫学家Hamers-Casterman教授以及他的同事们在骆驼的血清中发现了有别于传统抗体的新型抗体,这种新型抗体仅由两条重链构成,因此被称为重链抗体(heavy-chain antibody, HCAb)。重链抗体利用重链的可变区结合抗原VHH(variable domain of heavy chain o...
The absence of an Fc region prevents unwanted immune activation by avoiding Fc receptor binding, supporting precise mechanistic action. Engineered through the genetic fusion of two VHH domains via a flexible peptide linker, VHH nanoBiTE™ ensures robust antigen binding with reduced production ...
Indirect labeling using conjugated AffiniPure-VHH® Secondaries gives researchers more experimental scope by allowing them to use fluorophores to utilize wavelengths that may have been inaccessible when cloning in fusion tags such as GFP. Aside from the potential difficulty of adding a fusion tag onto...
Envafolimab developed by Alphamab Oncology, belonging to the PD-L1 single-domain antibody Fc fusion protein, was approved for marketing in November 2021 in China. In addition, presently, more than 20 nanobody-related drugs have entered the clinical stage. Clinical research progress of nanobody ...
Figure 1. Overview of scaffold selection, diversity design, and synthetic production of the NaLi-H1 library. The development of the NaLi-H1 library followed three lines of optimization. (i) A novel scaffold was defined by selecting a set of robust nanobodies using a CAT fusion assay (1)....
Rotman M;Welling MM;van den Boogaard ML;.Fusion of h Ig G1-Fc to 111In-anti-amyloid single domain antibody fragment VHH-pa2H prolongs blood residential time in APP/PS1 mice but does not increase brain uptake.Nucl Med Biol.2015.695-702...
However, at 48 h after systemic injection of the non-fused VHH-DTPA-111In and the VHH-Fc-DTPA-111In fusion protein in transgenic mice, the specific brain uptake of VHH-Fc-DTPA-111In was not improved compared to non-fused VHH-DTPA-111In. Conclusion Using VHH-Fc conjugates increases the ...