Also of interest is that among some VH3 anti-CHO antibodies in humans, those expressing a light chain have broader fine specificity than those containing a germline K L-chain product, which may explain the heterophilic nature of this patient's antibody to E. An IgM [lambda] antibody to Esc...
Single-domain antibodyPhage displayStable scaffoldNanobodyUsing conventional immunoglobulin G (IgG) molecules as therapeutic agents presents several well-known disadvantages owing to their large size and structural complexity, negatively impacting development and production efficiency. Single-domain antibodies (...
a Antibody information. V(D)J gene usage of heavy and light chains in 047-09_4F04, 241_2F04, 346-54, SFV009_3G01, and 222-1C06. 2009 MIV: monovalent 2009 pandemic H1N1 inactivated influenza vaccine; 2014 QIV: 2014-2015 quadrivalent inactivated influenza vaccine; cHA: cH8/1 and ...
Combinatorial antibody libraries were constructed from the spleen of a patient with concomitant systemic lupus erythematosus and idiopathic thrombocytopeni... M Behrendt,LJ Partridge,B Griffiths,... - 《Clinical & Experimental Immunology》 被引量: 40发表: 2003年 Depression and heart rate variability ...
Following primary antibody incubation, a goat antimouse (LI-COR, 926-32210, 1:10,000) or donkey antirabbit (LI-COR, 926–32213, 1:10000) conjugated to IRDye 800CW secondary antibody were used for detection on the LI-COR Odyssey (LI-COR, Bad Homburgh, Germany). Proliferation Assay ...
IgG autoantibodies eluted from RBCs of antiglobulin positive normal blood donors contained at least two antibody populations, an IgG autoantibody (Ab 1), and an IgG population (Ab 2) that agglutinated RBCs coated with some Rh(D) alloanti... SP Masouredis,MJ Branks,EJ Victoria - 《Blood》...
The anti-VH3-15 idiotypic antibody material, VH3-15 autoantibodies and cell surface antigens of the present invention can be used in methods for detecting, isolating and purifying VH3-15 polypeptides and in diagnostic assays for IBD and infection by Campylobacter jejuni. Nucleic acid molecules ...
The results may not accurately reflect that of natural antibody repertoire due to erroneous species annotation and the presence of man-made CDR loop diversity in public antibody sequence databases. In this study, in a precisely controlled germline context, we explored the relationship between amino ...
Abstract We prepared antiidiotypic (anti‐Id) antibody to 2 polyclonal IgM rheumatoid factors (IgM‐RF) and 2 polyclonal "hidden" IgM‐RF. The anti‐Id antibodies were isolated by chromatography on Sepharose 4B, to which was bound rabbit... TL Moore,TG Osborn,RW Dorner - 《Arthritis & Rh...
During convalescence, antibodies are subjected to affinity maturation, which enhances the antibody binding strength and generates new specificities that neutralize virus variants. Here, we performed a single-cell RNA sequencing analysis of spike-specific B cells from a SARS-CoV-2 c...