他们还发现,压力会反常地激活这些脑细胞,导致“微唤醒(microarousals)”,从而中断睡眠周期,缩短睡眠时间。相关研究结果于2023年12月13日在线发表在Current Biology期刊上,论文标题为“Regulation of stress-induced sleep fragmentation by preoptic glutamatergic neurons”。 虽然我们的身体在睡眠时处于休息状态,但是我们的...
Thestriatum, hippocampus, cerebral cortex and raphe nuclei express VGLUT3in a small number of neurons. Pancreatic 伪 and 尾 cells express BNPI andVGLUT2 in response to glucose concentrations. Human VGLUT3 shares a 72% sequence homology with VLGUT2 and BNPI.Aihara...
囊泡谷氨酸转运体(vesicular glutamate transporters,VGLUTs)能特异地装载谷氨酸进入突触囊泡并促进释放,它包括3个成员,其中VGLUT1和VGLUT2是谷氨酸能神经元和它们轴突末端高度特异的标志,同时VGLUT1标志着皮质-皮质投射,VGLUT2标志着丘脑-皮层投射。而VGLUT3则会出现在胆碱能中间神经元、5-羟色胺能神经元、海马和皮层...
Thus, vGluT2 is necessary for CA-RVLM neurons to activate respiration and increase vagal nerve activity.doi:10.1096/fasebj.28.1_supplement.1091.4Ben HollowaySteve AbbottKen ViarPatrice GuyenetFaseb Journal
whereas the lower brainstem and diencephalic regions express VLGUT2. Rat pinealocytes express both BNPI and VGLUT2. The striatum, hippocampus, cerebral cortex and raphe nuclei express VGLUT3 in a small number of neurons. Pancreatic a and b cells express BNPI and VGLUT2 in response to glucose...
Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons.Vong L , et al. Vglut2-Cre小鼠是一种用于神经科学研究的基因工程小鼠品系,这些小鼠在Vglut2(vesicular glutamate transporter 2)基因的控制下表达Cre重组酶。Vglut2基因编码一种囊泡型谷氨酸转运蛋白,主要存在于兴奋...
Moreover, most orexin neurons expressed VGLUT2, indicating these neurons are glutamatergic. Our data suggested that in the posterior hypothalamus there are four major distinct groups of neurons: VGAT+, orexin+/VGLUT2+, orexin-/VGLUT2+, and MCH neurons. This study facilitated our understanding of...
recycling is slower than VGLUT1-pH in both hippocampal neurons, which endogenously express mostly VGLUT1, and thalamic neurons, which endogenously express mostly VGLUT2, indicating that protein identity, not synaptic vesicle membrane or neuronal cell type, controls sorting. We characterize sorting ...
► VGLUT2 in mainly Nav1.8-expressing nociceptors is required to sense pain ► Removal of VGLUT2 in these neurons leads to sensitization of multiple itch pathways ► A pain-inducing stimulus is no longer able to mask itch in these mutant mice ► Our studies reveal a neural basis of ...
Neurons in the Vsp that send collateral projections to both the thalamus and the PBN were mainly VGLUT2 mRNA-positive, with a proportion of 90.3%, 93.0% and 85.4% in the oral (Vo), interpolar (Vi) and caudal (Vc) subnucleus of the Vsp, respectively. Moreover, approximately 34.0% of ...