While testing the hypothesis that "inhibiting inhibitory neurons" was sufficient to induce seizures, it was discovered that a mild electrical kindling protocol of VGAT-Cre mice led to spontaneous motor and electrographic seizures. This study characterizes these seizures and investigates the mechanism. ...
Ai14 mice harbor a loxP-flanked STOP cassette preventing the expression of the fluorescent protein tdTomato. When Ai14 mice were bred with VGLUT2-ires-Cre mice, tdTomato was observed in all VGLUT2+ neurons of the offspring. Four VGAT-EYFP mice (two male and two female) and four VGLUT2...
(1)Mice.We generated conditional EB2 knockout mice as a model of SAD and characterized the behaviors and the biochemical changes in the brains of the knockout mice.We also generated a mouse line with a selective deletion of EB2 from vGAT neurons by breeding a v GAT-Cre line with a ...