Fatty acids have long been considered essential to brain development; however, the involvement of their synthesis in nervous system formation is unclear. We generate mice with knockout of GPSN2, an enzyme for synthesis of very-long-chain fatty acids (VLCFAs) and investigate the effects. Both GP...
very-long-chain fatty acidsThe herbicide thenylchlor and its analogs inhibited the incorporation of [1-14C]oleate and [2-14C]malonate into very-long-chain fatty acids (VLCFAs) in Scenedesmus cells and leek microsomes from Allium porrum, respectively. Although the precise mode of interaction of ...
The paper decribes a method for the quantitative determination of long chain and very long chain fatty acids in serum of 22 blood donors with gas chromatography / mass spectrometry. The day-to-day precision was 2.5-8.6%; the recovery rate 89-120%. The results are discussed with results in...
Fig. 7: SK1 downregulation induces an increase of long-chain and very-long-chain Cer, in the context of oncogenic K-Ras overexpression. A–C SL analysis using tandem LC/MS/MS in cells overexpressing Vect or mutant GV K-Ras. Cells were plated and transfected the next day with control (...
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Feeding pigs with very-low protein (VLP) diets while supplemented with limiting amino acids (AA) results in decreased growth. The objective of this study was to determine if supplementing VLP diets with branched-chain AA (BCAA) would reverse the negative
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Novel self-healing resin-based composites containing microcapsules are created to enhance the mechanical overall performance of dental restorations. However, the long-lasting exhaustion behaviour of the self-healing composites has actually however been barely investigated. Consequently, this manuscript studied...
Concerning SLs with very long acyl chains, it is however of great importance to consider the effects of both bilayer leaflets when evaluating their membrane behavior. The very long acyl chain provides the SL molecule with a chain length asymmetry at the bilayer midplane, where the acyl chain ...
Very-long-chain acyl-CoA dehydrogenase deficiency (VLCAD) is the most common defect of long-chain fatty acid beta-oxidation. The recommended treatment includes the application of medium-chain triacylglycerols (MCTs). However, long-term treatment of VLCAD(-/-) mice resulted in the development of ...