125 mg BID) compared to three-times-daily dosing of telaprevir (750 mg; q8h). This trial is expected to enroll approximately 700 treatment-naïve people with genotype 1 hepatitis C in two telaprevir-based treatment
BOSTON--(BUSINESS WIRE)--Vertex Pharmaceuticals Incorporated (Nasdaq: VRTX) today announced positive results from its once-daily vanzacaftor/tezacaftor/deutivacaftor (the “vanza triple”) program, the most comprehensive Phase 3 pivotal program ever conducted by Vertex for the treatment of cystic fib...
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_x2, _x4 and _d2 are scaling modifiers for inputs, whereby the output is scaled by two times, four times, and one-half of the input value, respectively. In short, these are advantageous modifiers in graphics operations, and have sometimes been custom coded by the developer to achieve ...
Compound I, deuterated derivatives of Compound I, and pharmaceutically acceptable salts of Compound I or its deuterated derivatives can be independently administered once daily, twice daily, or three times daily, optionally in combination with one or more of Compounds II, III, III-d, and IV, and...
pregabalin, a gabapentinoid, may be enough for Vertex. At an investor event last month, Stuart Arbuckle, chief operating officer at Vertex, said gabapentinoids have “variable” efficacy and a “significant tolerability profile.” VX-548 is given less frequently, once daily ver...
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The present invention relates to compounds of formula IVA, formula IVB, or formula IVC, useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, inclu
In certain embodiments, the compounds of the invention may be administered orally or parenterally at dosage levels of about 0.01 mg/kg to about 50 mg/kg and preferably from about 1 mg/kg to about 25 mg/kg, of subject body weight per day, one or more times a day, to obtain the ...