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of config.site or have multiple versions, you can save the file to a different filename, and then refer to it like this ./configure CONFIG_SITE=<config site file> Note 3: GSNAP is designed for short reads of a limited length, and uses a configure variable called MAX_READLENGTH (...
Then, we study variants of the coding part of DNA (exome), using next generation sequencing (NGS) process on trio (mother, father, child). Bio-informatics tools (RVIS, PolyPhen-2) are used to prioritize disease-causing mutations in candidate genes. The inclusion period...
Soon enough the time will come when you are too tired to move farther than the terrace of the best hotel. Go now.No need, you may say, to tell that. But what I need to tell you is that you will meet with a surprising amount of opposition the moment you try to set out. Rubbish...
A new chemical synthesis strategy to harvest the rich information found in natural products—organic compounds isolated from natural sources—has led to the identification of novel, simpler derivatives with potential to selectively protect neurons, impor
In this chapter which is a continuation of the previous one, we consider two restricted version of the QAP: the Anti -Monge—Toeplitz QAP and the KalmansonToeplitz QAP. The Anti -Monge—Toeplitz QAP is a restricted version of the QAP, where one of the coefficient matrices is a left-higher...
To reduce computational complexity, we further extract the top 8000 genes based on the big variance among samples in gene expression while keep all the features in the miRNA expression dataset because of the small number of miRNAs. The miRNA precursor names are used to represent each of the ...
Transversions (Tv’s) are more likely to alter the amino acid sequence of proteins than transitions (Ts’s), and local deviations in the Ts:Tv ratio are indicative of evolutionary selection on genes. Whether the two different types of mutations have different effects in non-protein-coding sequ...
continuous runs of guanine) can stack on top of each other to form a G4,stabilized by monovalent cation/s. The unimolecular versions occur naturally near the ends of the chromosomes, better known as the telomeric regions, and in transcriptional regulatory regions of multiple genes, both in micr...
2.2. The Identification and Analysis of 19 Reference Compounds Nineteen reference compounds which might represent the major structural types of the DBTs were analyzed. The characteristic fragment ions of 19 references are very useful for determining the structural skeleton and the substitution patterns of...