ventilated patients rely on changes to ventilator settings to manage their systemic pH balance. Patients with increasing CO2levels should first be removed from the ventilator and assessed for tube displacement, pulmonary edema, and pneumothorax. The...
As a result, the effect of PTF on the incidence of VAP warrants validation by large, well-conducted RCTs in different settings [55]. To address this call, the VIP study is a large-sample-sized, rigorous multicenter randomized trial that aims to determine whether PTF is effective and safe ...
Our study does not extensively discuss the generalizability of the model to other clinical settings or diverse patient populations. This raises questions about the external validity of our findings. 5. Our study does not cover whether the model's predictions have been validated in actual clinical ...
Last, the findings of this single-center study in a tertiary care hospital may not be generalizable to other settings. Conclusions We found that ventilator bundle components differ in their associations with VAEs, duration of mechanical ventilation, and other outcomes. Sedative infusion interruptions ...
First, we included patients with diverse diseases and admitted in multiple ICU settings. Although this led to a more global approach to our primary question, the differences between the ages and disease processes may have influenced our outcomes. For instance, the inclusion of patients in the ...
Administration of sedative and opioid medications to patients receiving mechanical ventilatory support in the intensive care unit is a common clinical practice. Methods A two-site randomized open-label clinical trial will test the efficacy of self-management of sedative therapy with dexmedetomidine compared...
Many questions concerning the mechanisms of VILI in surgical patients remain unanswered. The optimal threshold value of each ventilator parameter to reduce VILI is also unclear. Further experimental and clinical studies are necessary to better evaluate ventilator settings during the perioperative period in...
Ventilator-associated pneumonia (VAP) is a common cause of nosocomial infection, and is related to significant utilization of health-care resources. In the
Although there are still unanswered questions, especially concerning the most efficient use of these technologies, our study suggests that implementing HITB-RIC may be a viable strategy to improve access to high-quality ICU care in the setting of an inadequate supply of qualified intensivists. ...
the CASP checklist. Questions from section C in the CASP for diagnostics checklist “will the results help locally?” were not included in our scoring as the main aim of the review was not related to the local application of the diagnostic procedures. Studies were assigned a score of ‘1...