target in the subject; providing a drug, the drug being a small molecule agent that blocks the first target or a second target in the subject; connecting the antibody and the drug with a linker to form an Antibody-Drug Synergism (ADS) compound; and treating the disease with the ADS ...
4. Phase 1 Dose-Escalation Study of STRO-002 in Patients with Advanced, Progressive, Platinum-RR Epithelial Ovarian Cancer -ASCO 2021 5. First-in-Human Phase 1 Study of MORAb-202, an Antibody-Drug Conjugate Comprising Farletuzumab Linked to Eribulin Mesylate, in Patients with Folate Receptor-...
4. Phase 1 Dose-Escalation Study of STRO-002 in Patients with Advanced, Progressive, Platinum-RR Epithelial Ovarian Cancer -ASCO 2021 5. First-in-Human Phase 1 Study of MORAb-202, an Antibody-Drug Conjugate Comprising Farletuzum...
血管内皮生长因子(VEGF)抑制剂是一类与 VEGF-A 结合,阻止其与 VEGF 受体 2(VEGFR-2)结合的单克隆多聚体药物。由于其具有抑制血管生成的能力而成为治疗恶性肿瘤和眼部疾病的有力工具,目前常用的抗 VEGF 药物有雷珠单抗、贝伐单抗、阿柏西普等。有数据表明,玻璃体内注射 VEGF 抑制剂可导致显著的全身吸收以及血浆 VE...
- 《Nature Reviews Drug Discovery》 被引量: 4640发表: 0年 Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen. The Fab portion of a humanized (Fab-12; IgG form known as rhuMAb ) to vascular endothelial () has ...
Systemic anti-tumor necrosis factor antibody treatment exacerbates endotoxin-induced uveitis in the rat Tumor necrosis factor is released in the circulation and aqueous humor during endotoxin-induced uveitis, and induces acute uveitis when injected intraocula... AFD Vos,MACV Haren,C Verhagen,... -...
6107 POSTER Improved Overall Survival in the Patients With Metastatic Colorectal Cancer Associated With Ant-VEGF Antibody Drug and Anti-EGFR Antibody Drug Administrationdoi:10.1016/S0959-8049(11)71752-XDenda, T.Nakamura, N.Sudo, K.Nakamura, K....
v. injection of GLV-1h68 and multiple i.p. injections of Avastin. Taken together, the VACV-mediated delivery and production of immunotherapeutic anti-VEGF scAb in colonized tumors may open the way for a unique therapy concept: tumor-specific, locally amplified drug therapy in humans. 展开 ...
英文名称: Anti-Mouse VEGF-A Antibody (2G11-2A05) 总访问: 31 国产/进口: 进口 半年访问: 24 产地/品牌: MedChemExpress(MCE) 产品类别: 生化试剂 规格: 1 mg; 5 mg 最后更新: 2024-11-4 货号: HY-P990148 CAS 号: 参考报价: 2200; 6500 立即询价 电话咨询 ...
(CD5 antigen-like precursor) as an important gene upregulated in response to antiangiogenic therapy leading to the emergence of adaptive resistance. By using both an RNA-aptamer and a monoclonal antibody targeting CD5L, we are able to abate the pro-angiogenic effects of CD5L overexpression in ...