Different types of viruses may be used as vectors, including adenoviruses, adeno-associated viruses, baculoviruses, herpes simplex viruses, poxviruses, and retroviruses. These vectors either become integrated into host cell DNA or, within host cells, temporarily express the genes they carry. Gene expr...
Maríade las Mercedes Segura, ...AlainGarnier, inBiotechnology Advances, 2006 Retroviral vectorshave attracted the attention of gene therapy researchers for their ability to stably integrate the transgene of interest into the target cell genome providing the possibility of long-term gene expression and...
vector-mediated gene transfer have been explored.16Efficient genome editing ofCCR5in HSPC with HD-Ad5/35 vectors expressing site-specific endonucleases is mediating positive results in AIDS clinical trials; expression under microRNA regulation can be a useful tool for therapeutic and biotechnology ...
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Agro-infiltration of leaf tissue with binary vectors harbouring a sequence of interest is a rapid method of expressing proteins in plants. It has recently ... F Sainsbury,EC Thuenemann,GP Lomonossoff - 《Plant Biotechnology Journal》 被引量: 601发表: 2010年 Efficient production of chimeric Huma...
VVS can be modified and applied in a variety of fields in biotechnology and medicine in addition to their use in targeted drug delivery. VVS is a favorable platform for vaccine and gene delivery. State-of-the-art vaccine delivery systems involve the encapsulation mRNA-based vaccines with lipid-...
Ad5-nCoV (trade name: Convidecia) is a first-generation E1/E3-deleted Ad5 based vector carrying the full-length SARS-CoV-2 spike glycoprotein (Fig.2a), developed in China by CanSino Biologics Inc. and the Beijing Institute of Biotechnology in early 2020. A summary of the preclinical data...
D.F.Chowdhury, inComprehensive Biotechnology (Second Edition), 2011 5.49.3.2Gene Therapy Gene therapy is the process by which defective genes are replaced with functional ones, by using a gene to promote cells to produce their own proteins. Appropriately designed gene sequences may be introduced in...
Stephen R. Decker, in Biotechnology Advances, 2015 Expression vector for cbh1Δ strain AST1116 We designed and constructed the expression vector, pTR50 (Fig. 7) for expression of various cellobiohydrolases and other proteins in the T. reesei strain AST1116. This vector contains the E. coli ...
Nature Biotechnology volume 40, page 1316 (2022)Cite this article 1757 Accesses 6 Citations 3 Altmetric Metrics details To the Editor— It was with much interest that I read the News article by Cormac Sheridan ‘Topical herpesvirus gene therapy enters final lap’, about the treatment of ...