Gene therapy, the introduction of therapeuticgeneticmaterial to cells to ameliorate disease orinjury, holds great potential for the treatment of numerous disorders. However, broad clinical application of gene therapy is currently hindered by the need for safer and more efficient delivery vectors. Vector...
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S. Deep generative models of genetic variation capture the effects of mutations. Nat. Methods 15, 816–822 (2018). Article CAS PubMed PubMed Central Google Scholar Sevgen, E. et al. ProT-VAE: Protein Transformer Variational AutoEncoder for functional protein design. Preprint at bioRxiv ...
Transposable elements are mobile genetic components that can be used for experimental and therapeutic purposes. The Sleeping Beauty (SB) transposon, originated from fish genomes, is well characterized and used as a vector system (Kebriaei et al., 2017). The SB vector has not been investigated ...
These studies indicate that genetic diversity of JEV isolates is driven by local virus transmission cycles rather than virus introduction from distant regions for instance by migratory birds36,37. Researchers have proposed that overwintering occurs in vertebrate hosts such as bats, in cold-blooded ...
and specific conjugation techniques and methods. We will also provide some insights into how these modifications improve the target specificity of VVS as a delivery system for various cargoes such as drugs and genetic materials. Challenges, limitations, and perspectives for future studies on VVS are ...
[56]. In addition, genetic differentiation was detected even in mosquitoes collected within the same cities, except for Preah Sihanouk; the exception of Preah Sihanouk is probably due to it being the province with the heaviest rainfall in Cambodia, thereby creating more larval habitats and ...
The reduction of malaria burden in endemic and epidemic regions mainly depends on knowledge of the malaria-transmitting mosquito species, populations and behavioural characteristics, as well as malaria exposure risks. This work aimed at carrying out a holistic study in order to characterise Anopheles ...
Physical delivery Gene gun, electroporation, Ultrasound waves Introduction of genetic material using mechanical force to generate holes in membranes [77] Viral vector delivery Retrovirus, Lentivirus, Herpes virus, Adenovirus, Adeno-associated virus Introduction of genetic material enclosed in a viral particl...
S. Deep generative models of genetic variation capture the effects of mutations. Nat. Methods 15, 816–822 (2018). Article CAS PubMed PubMed Central Google Scholar Sevgen, E. et al. ProT-VAE: Protein Transformer Variational AutoEncoder for functional protein design. Preprint at bioRxiv ...