Using the cytoplasmic domain to attach to several protein partners, including p120, 尾-catenin and plakoglobin, VE-cadherin partly regulates the endothelial permeability. VE-cadherin is also associated with tumour progression, epithelial to mesenchymal transition (EMT) and angiogenesis. It is of pivotal...
上皮极性转而获得成纤维细胞样表型.越来越多的研究证实钙粘蛋白的异常表达或钙粘蛋白间的相互转化,是某些类型癌症EMT过程中的关键进程.VE-Cadherin在某些恶性肿瘤中的异常表达已经被发现,且体外TGF-β介导的乳腺肿瘤细胞EMT过程中VE-cadherin表达出现上调.我们的研究着力于VE-cadherin在肺癌细胞系中的表达及其与EMT过程...
(Fig. 1). Cadherins comprise of a large family of proteins with over 110 known members in humans with multiple functions. In a context of cancer, E-cadherin acts as atumor suppressor. E-cadherin expression inhibits tumor progression by controllingepithelial to mesenchymal transition(EMT) that ...
肉瘤样癌的组织起源,并且对实验组22例组织切片进行VE-cadherin、EphA2、MMP2、VEGF、Hif-1α免疫组化染色,分析肺肉瘤样癌中VM的临床意义及EMT促进VM形成的相关... 郑旭 - 天津医科大学 被引量: 1发表: 2014年 食管鳞癌血管生成拟态的组织学和细胞学研究 观察RNAi沉默VE-cadherin对食管鳞癌Eca109血管生成拟态形成...
Vascular Endothelial Cadherin Promotes Breast Cancer Progression via Transforming Growth Factor Signaling Epithelial-to-mesenchymal transition (EMT) is an important event during carcinoma progression and leads to increased tumor cell malignancy. Here, we show t... M Labelle,HJ Schnittler,DE Aust,... ...
Other protein that has been identified to have a prominent role in EMT is Twist1. This protein binds DNA using similar E-box sequence motifs repressing E-cadherin and up-regulating mesenchymal markers expression; over-expression of Twist1 significantly enhanced cell mobility, invasiveness and promoted...
采用简单随机法抽取其中4例食管鳞癌患者组织标本进行Western blotting检测STAT3与E-cadherin的表达情况.采用RT-qPCR及Western blotting方法分别检测3株食管鳞癌细胞株中STAT3与E-cadherin表达,筛选其中高表达的1株进行转染,利用STAT3小干扰RNA作为实验组,以双链无义RNA转染作为对照组,检测STAT3,E-cadherin表达水平变化,并...
breast cancer;human umbilical vein endothelial cells (HUVEC);epithelial-mesenchymal transition (EMT);cadherin switching;extracellular vesicles (EVs);invasion;vascular mimicry (VM) 1. Introduction Cadherins are a family of cell adhesion molecules that enable cells to seclude themselves from cells of other...
(SOX2),血管内皮生长因子(VEGF),上皮钙黏蛋白(E-cadherin)和神经钙黏蛋白(N-cadherin)蛋白表达,ELISA检测MCF-7细胞上清液iNOS和IL-1β水平.结果与对照组相比,... 王聆宇,李文忠,罗仕云,... - 《细胞与分子免疫学杂志》 被引量: 0发表: 2022年 VEGF和SOX2在胃癌中的表达及与预后的关系 目的:本研究旨在...
Epithelial-to-mesenchymal transition (EMT) is a developmental process hijacked by cancer cells to leave the primary tumor site, invade surrounding tissue and establish distant metastases. A hallmark of EMT is the loss of E-cadherin expre... SN Steinway,Jorge Gomez Tejeda Zaudo,PJ Michel,... ...