nMS-873是一种有效的,选择性的VCP/p97抑制剂,在1mM ATP条件下,IC50值为20nM。注:本品仅可用于科研实验,严禁用于临床医疗及其他用途!CAS号:1418013-75-8纯度:99.93%分子式:C27H28N4O3S2分子量:520.67结构式:储存条件:-20℃,有效期2年,溶入溶剂后-20℃请尽量在一个月内使用。相关搜索:VCP/p97抑制剂(NMS...
NMS-873 is a potent, selective allostericVCP/p97inhibitor with anIC50value of 30 nM. IC50& Target IC50: 30 nM[1] 细胞效力 (Cellular Effect) Cell LineTypeValueDescriptionReferences BTI-TN-5B1-4IC50 0.024 μM Inhibition of human recombinant His-GST tagged VCP expressed in baculovirus infected...
NMS-873 is a selective inhibitor of VCP with IC50 value of 30nM [1]. NMS-873 is the most potent and specific VCP inhibitor. It shows similar potency against both wild-type VCP and VCPC522T without affecting the oligomeric state of VCP. NMS-873 is selective against all of the AAA AT...
生命科学试剂和试剂盒_VCP Inhibitor III, NMS-873VCP Inhibitor III, NMS-873会员价请登录市场价￥2211原厂型号 5.31088.0001 贝雷猫货号 RH156141 品牌 默克密理博/Millipore 单件重量 1kg 货期 45天 单位: 盒 包装: 盒 库存: 0 数量: 盒 + - 1盒起订,增量1盒 ...
Our results reveal that most VCP-adaptor interactions are characterized by rapid dynamics that in some cases are modulated by the VCP inhibitor NMS873. These findings have significant implications for both the regulation of VCP function and the impact of VCP inhibition on different VCP-adaptor ...
In addition, PPA is able to inhibit proliferation of two HCT116 cell lines that are resistant to CB-5083 and NMS-873, respectively. Proteomic analysis of PPA-treated HCT116 revealed Gene Ontology enrichment of known p97 functional pathways such as the protein ubiquitination and the ER to Golgi...
Cells resistant to CB-5083 have been shown to harbor mutations in VCP, yet details regarding the mechanism of resistance are unknown.23 Similarly, prolonged treatment with an allosteric VCP inhibitor, NMS-873, resulted in a heterozygous A530T mutation in VCP. However, these resistant cell lines ...
1c, d) or treatments with various VCP inhibitors, including eeyarestatin-1 (Eer1, an ER membrane-binding domain-containing VCP inhibitor) [30], CB-5083 (an inhibitor of the D2 ATPase domain of VCP) [31], and NMS-873 (an allosteric VCP inhibitor) [32] (Fig. 1e, f). Next, we...
The cells were incubated up to 48 h and treated with the allosteric VCP inhibitor NMS873 (10 μM, 8 h). The cells were lysed and subjected to fractionation for biochemical analysis. (B) WB analysis of HEK293T-transfected cells. Lanes 1–5 correspond to DMSO-treated cells and lanes 6–...
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