Vav-iCre 小鼠是一种基因工程小鼠品系,广泛用于研究造血系统和免疫系统的基因功能。 特点与应用 1.Cre表达驱动基因 •Vav基因启动子:Vav 基因主要在造血系统细胞中表达,包括造血干细胞 (HSC)、淋巴细胞、髓系细胞和红细胞前体等。 •组织特异性表达:Cre 重组酶在血液和免疫系统细胞中特异性表达,使其成为研究造...
Vav-iCre小鼠,将两种基因型小鼠杂交,所产生的子代中有基因型为beclin1~(f/f);Vav-iCre(本文简写为beclin1-/-)的小鼠,即造血系统中beclin1双等位基因敲除的胎鼠.由于纯合敲除小鼠在围产期18.5-19.5天全部死亡,我们选取胚胎期18.5天的胎鼠进行后续功能检测.(2)beclin1~(f/f);Vav-iCre胎鼠的鼠尾基因组DNA...
Two widely used transgenes for conditional gene recombination in hematopoietic cells are Vav-iCre driven from the murine Vav1 promotor, and hCD2-iCre driven from the human CD2 promotor. Vav-iCre expresses active Cre in fetal and adult hematopoietic stem cells and all descendants, hCD2-iCre ...
We constructed a Pig-a conditional knock-out mice model by ES targeting technique and Vav-iCre. The expressions of GPI and GPI-AP were almost completely absent in CKO homozygote mice, and the proportion of the deficiency remained stable from birth. In CKOheterozygote mice, the proportion of ...
Extended Data Fig. 2: Vav-iCre+/−;Ercc1−/fl mice maintain normal weight and body composition. From: An aged immune system drives senescence and ageing of solid organs a, Body weight (BW) of three different age groups of mice by genotype. b–d, Percentage fat (b), lean mass (...
目的:探索Vav-Cre介导的黄色荧光蛋白(YFP)报告基因系统标记小鼠体内自然杀伤(NK)细胞的特异性和效率。方法通过基因型分型筛选ROSA26R-YFP与Vav-Cre小鼠杂交后代中双阳性基因型小鼠,流式细胞术分析免疫器官淋巴结、脾、胸腺以及骨髓细胞的YFP表达效率,通过细胞表面抗体标记淋巴结、脾及骨髓的NK细胞,... 查看全部>> ...
it is urgent to establish a stable animal model. We constructed a Pig-a conditional knock-out mice model by ES targeting technique and Vav-iCre. The expressions of GPI and GPI-AP were almost completely absent in CKO homozygote mice, and the proportion of the deficiency r...
其次,为了证明Vav-iCre+/−;Ercc1−/fl小鼠的免疫细胞在反式中驱动继发性衰老和衰老病理,从突变小鼠和两岁野生型小鼠分离脾细胞,然后将其移植到p16ink4a荧光素酶报告小鼠,发现将来自Vav-iCre+/−;Ercc1−/fl或老年野生型小鼠的脾细胞移植到年轻小鼠体内可诱导反式衰老,而移植年轻免疫细胞可减弱衰老。
问:耳朵里疼的根本受不了,怎么可以止疼(男,24岁) 答:一般耳道感染多是细菌或病毒感染后引起的,最好不用止痛药,容易掩盖病情,您的这种情况应该是急性中耳炎或外耳道炎引起的,最好是去当地正规医院的耳鼻喉科检查一下,可以考虑做理疗,同时做个血液分析,根据情况在选用
收藏:0 性别:雄 / 雌 周龄:3～8周 繁育方式:杂合 X 野生 品牌:鼠来宝生物 声明:仅用于科学研究,不得用于临床诊断或治疗 产品详情 产品评论(0) 友情链接: 迪米特(试剂耗材) 守正弘药(动物实验) Jackson Laboratory Mouse Genome Informatics (MGI)