TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 220 iu/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research...
2.1 Preparation of Solution Inspect parenteral drug products for particulate matter and discoloration prior to use, whenever solution and container permit. Vasopressin Injection Solution for Dilution, 20 units per mL Dilute vasopressin injection in normal saline (0.9% sodium chloride) or 5% dextrose ...
79 A recent meta-analysis of vasopressin for cardiac arrest did not demonstrate any overall benefit or harm.80 In a pediatric porcine model of prolonged VF, the combination of vasopressin and epinephrine resulted in greater left ventricular blood flow than either drug alone, and both vasopressin ...
By taking the volume of distribution as 67ml/kg body weight (assuming one compartment kinetics) for the antagonist, one can readily calculate a "pA 2 " value (-logM) for this concentration. This type of analysis in vivo assumes that (i) the antagonist drug has achieved equilibrium in the...
Neuropsychopharmacology REVIEWS behavior was measured in the acute phase of drug delivery as well as in the long term. Immediately after drug delivery, male juveniles receiving intranasal oxytocin showed increases in social behavior (contact time) with a familiar cage mate and decreased time spent ...
(AAV adeno-associated DREADD virus infusion into the hypothalamic paraventricular (PVN) and supraoptic (SON) nuclei; AVP arginine vasopressin; arrow=drug infusions; FIT female intruder test, IS social isolation, OXT oxytocin, OXTR-A OXT receptor antagonist, SURG surgery, V1aR-A V1a receptor ...
Title:Vasopressin CAS Registry Number:9034-50-8 Additional Names:Antidiuretic hormone; beta-hypophamine;b-hypophamine Trademarks:Pitressin (Warner-Lambert); Pressyn (Ferring) Literature References:The water-soluble pressor principle prepd by synthesis or obtained from the posterior lobe of the pituitary...
Midodrine is avasopressorand antihypotensive drug used to treat low blood pressure. Midodrine is available under the following different brand names: ProAmatine, and Orvaten. What's the definition of vasopressin? :a polypeptide hormone secreted by the posterior lobe of the pituitary gland or obtain...
Curr. Drug Metab. 2017, 18, 306–345. [Google Scholar] [CrossRef] Carmosino, M.; Brooks, H.L.; Cai, Q.; Davis, L.S.; Opalenik, S.; Hao, C.; Breyer, M.D. Axial heterogeneity of vasopressin-receptor subtypes along the human and mouse collecting duct. Am. J. Physiol. Renal ...
Drug Targets 2016, 16, 276–287. [Google Scholar] [CrossRef] Ludwig, M.; Bull, P.M.; Tobin, V.A.; Sabatier, N.; Landgraf, R.; Dayanithi, G.; Leng, G. Regulation of activity-dependent dendritic vasopressin release from rat supraoptic neurones. J. Physiol. 2005, 564 Pt 2, 515...