Vascular dementia is the second-most-common type of dementia. Vascular cognitive impairment is a term encompassing vascular dementia as well as milder forms of pre-dementia cognitive impairment related to vascular damage that do not meet the criteria for a diagnosis of dementia. Early diagnosis of ...
After cardiovascular diseases, cerebrovascular diseases are the second leading cause of death worldwide. Vascular aging-related cerebrovascular diseases, including ischemic stroke, intracerebral hemorrhage (ICH), and vascular dementia, represent a massive burden on economic and social health.200Therefore, the...
In severe cases, the progressive deposition of Aβ ultimately diminishes the integrity of the affected cerebral blood vessels and can lead to smooth muscle cell degeneration, microbleeds, intracranial hemorrhages and stroke, which can all contribute to vascular cognitive impairment and dementia (3). ...
Familial Aβ mutations, such as Dutch-E22Q and Iowa-D23N, can cause severe cerebrovascular accumulation of amyloid that serves as a potent driver of vascular cognitive impairment and dementia. The distinctive features of vascular amyloid that underlie its unique pathological properties remain unknown...
Keage HA, Carare RO, Friedland RP, Ince PG, Love S, Nicoll JA, Wharton SB, Weller RO, Brayne C (2009) Population studies of sporadic cerebral amyloid angiopathy and dementia: a systematic review. BMC Neurol 9:3. doi:10. 1186/1471-2377-9-3 37. Launer LJ, Hughes TM, White LR (...
Subcortical vascular dementia (sVAD) is considered the most frequent dementia in old population, and it is due to a small vessel disease. It has a very specific nosography, where the dominant factors are dysexecutive functions, depression, and apathy. Very few studies described visual hallucinations...
Kalimo H, Ruchoux M-M, Viitanen M, Kalaria RN (2002) CADASIL: a common form of hereditary arteriopathy causing brain infarcts and dementia. Brain Pathol 12:371–384 CAS PubMed Google Scholar Tikka S, Mykkänen K, Ruchoux M-M, Bergholm R, Junna M, Pöyhönen M, Yki-Järvinen ...
Amyloid-β deposition within cerebral capillaries has been consistently associated with the apolipoprotein E ε4 allele and is frequently concomitant with Alzheimer’s disease [66]. Accumulating lines of evidence have shown CAA plays a pivotal role in the pathogenesis of dementia [36,47]. Structural...
Amyloid-β deposition within cerebral capillaries has been consistently associated with the apolipoprotein E ε4 allele and is frequently concomitant with Alzheimer’s disease [66]. Accumulating lines of evidence have shown CAA plays a pivotal role in the pathogenesis of dementia [36,47]. Structural...
International Journal of Molecular Sciences Review Molecular Pharmacology of Rosmarinic and Salvianolic Acids: Potential Seeds for Alzheimer's and Vascular Dementia Drugs Solomon Habtemariam Pharmacognosy Research Laboratories & Herbal Analysis Services, University of Greenwich, Central Avenue, Chatham-Maritime,...