Vascular calcification is a detrimental pathology ubiquitously present in a number of vascular disease processes. Anatomically, vascular calcification is recognized in the intima or the media of the arterial wall although both sites may be involved simultaneously. Intimal calcification is exclusively ...
Vascular calcifications are frequently found among dialysis patients, and the calcification process may influence the patient's outcome. The aim of the present study was to determine the role that vascular calcifications may have on autologous arteriovenous fistula (AVF) survival.This study included 90...
Apoptosis of VSMCs can lead to thinning of the fibrous cap and promote the formation of necrotic core, plaque rupture, and calcification [35]. Apoptotic levels of VSMCs are low in early plaques but increase with the progression of lesions, which is why VSMC death can distinguish the ...
BACKGROUND AND PURPOSE: Atherosclerotic calcifications are present not only in the extracranial carotid bifurcation but also in the intracranial part of th... TTD Weert,H Cakir,S Rozie,... - 《Ajnr Am J Neuroradiol》 被引量: 182发表: 2009年 New face of an old enzyme: alkaline phosphatase...
Although we investigated a selected group of younger ESRD patients, histological evidence of medial vascular calcification was present in 42% of the patients, confirming premature vascular aging in ESRD.2,3 The increased cardiovascular risk in the calcified group is mirrored by elevated troponin T. ...
Vascular calcification is common in chronic kidney disease (CKD) and contributes to cardiovascular disease (CVD) without any effective therapies available up to date. The expression of soluble epoxide hydrolase (sEH) is different in patients with and without vascular calcification. The present study in...
BACKGROUND: Cardiovascular morbidity and mortality are highly prevalent in haemodialysis (HD) patients and have been recently associated with vascular calcifications. The objective of our study was to assess the value of a simple vascular calcification score for the prediction of cardiovascular death, ...
In our present study, we found that exosomes secreted by 3.5 mM inorganic phosphorus (HPi) induced AFs (AFsHPi-Exos) significantly promoted the calcification of VSMCs compared with exosomes secreted by 0.9 mM inorganic phosphorus (NPi) induced AFs (AFsNPi-Exos). After inhibiting the biogenesis ...
Dellegrottaglie S, Saran R, Rajagopalan S. Vascular calcification in patients with renal failure: culprit or innocent bystander? Cardiol Clin 2005; 23: 373-384 [PMID: 16084285 DOI: 10.1016/ j.ccl.2005.04.001]Dellegrottaglie S, Saran R, Rajagopalan S. Vascular calcifi- cation in patients with...
(AMP-activated protein kinase),196,197,198have been thought to be main pathway in apoptosis of VSMCs stimulated by phosphate. Contractile VSMCs converting into osteo-phenotype is also responsible for vascular calcification. Under high extracellular phosphate levels circumstances, VSMCs will undergo ...