variants of concernvaccine neutralization efficacyseraSera obtained from convalescent individuals, and vaccinated individuals can induce low neutralizing efficacy against variants of concerns (VOCs) of SARS-CoV-2. In addition, the majority of COVID-19 vaccines are less efficacious against VOCs when ...
In conclusion, we notice that the utility of funnel plots is not limited only to epidemiological setting, but have also meaningful clinical implications. Indeed, several papers22,23show that VOCs have a reduced sensitivity to both antiviral drugs and monoclonal antibodies. The capacity to detect VOC...
As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to rage globally, we have been witnessing the rapid emergence and turnover of multiple variants of concerns (VOCs) such as Alpha (B.1.1.7) initially found in the United Kingdom; Beta (B.1.351) in South Africa;...
Here we show that unlike the initial virus, VOCs are able to infect common laboratory mice, replicating to high titers in the lungs. This host range expansion is explained in part by the acquisition of changes at key positions of the receptor binding domain that enable binding to the mouse ...
The substitution of L18 to a F (Phenylalanine) is found in VOCs Beta and Gamma [4-7]. The L18F mutation has been predicted to impact mAb binding, based on structural data [13, 21]. Further functional studies are now required to assess this hypothesis. ...
Evaluation of HLA class I stabilizing activity for 18 globally prevalent alleles identifies CD8+ T cell epitopes within highly networked regions with limited mutational frequencies in circulating SARS-CoV-2 variants and deep-sequenced primary isolates. Moreover, these epitopes elicit demonstrable CD8+ T...
Early data suggest that RBD mutation N501Y emerged recurrently in multiple regions due to increased transmissibility, and is associated with multiple VOCs [89,99,100,158] (Table5). SARS-CoV-2 N501 serves as one of six critical S residues required for binding to ACE2 [159] and N501Y increas...
Emerging SARS-CoV-2 variants of concern (VOCs) harboring multiple mutations in the spike protein raise concerns on effectiveness of current vaccines that rely on the ancestral spike protein. Here, we design a quadrivalent mosaic nanoparticle vaccine disp
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) continue to wreak havoc across the globe. Higher transmissibility and immunologic resistance of VOCs bring unprecedented challenges to epidemic extinguishment. Here w
> Cover mutations of VOCs (Alpha/Beta/Delta/Gamma/Lambda/Omicron variants): Alpha (Cat. No.SPN-C52H6), Beta (Cat. No.SPN-C52Hk), Gamma (Cat. No.SPN-C52Hg), Delta (Cat. No.SPN-C52He),Lambda (Cat. No.SPN-C52Hs),Omicron (Cat. No.SPN-C52Hz) ...