However, vaccine efficacy (VE) can be jeopardised by the rapid emergence and spread of SARS-CoV-2 variants of concern (VOCs) that could escape from neutralising antibodies and/or cell-mediated immunity. Rare adverse events have also been reported soon after administration of viral vector and ...
Early detection of the emergence of a new variant of concern (VoC) is essential to develop strategies that contain epidemic outbreaks. For example, knowing in which region a VoC starts spreading enables prompt actions to circumscribe the geographical area where the new variant can spread, by conta...
Asymptomatic RT-PCR positive COVID-19 patients in orthopaedic pre-operative evaluation during the peak of the second wave 2022, Clinical Infection in Practice Citation Excerpt : In particular, VOC B.1.617.2/Delta has surpassed all previous VOCs in Bangladesh, posing a major threat to country's ...
The increased infectivity and transmissibility of SARS-CoV-2 variants of concern (VOCs) could cause significant human and economic damage. Hence, understanding their characteristics is crucial to control infection. We evaluated the environmental stability of the Wuhan strain and all VOCs (Alpha, Beta,...
The rapid and widespread transmission of SARS-CoV-2 has led to the emergence of multiple variants of concern (VOCs), most notably the Omicron variant, which continues to evolve and diversify into a range of sub-lineages. Our previous research has shown that these Omicron sub-lineages, spanning...
Despite these efforts, the control of the pandemic was hampered by the emergence of new variants called “Variants of Concern” (VOCs) for which the first generation of vaccines was less effective in reducing transmission [2,3,4,5]. Additionally, humoral immunity levels decreased within months ...
most current variants of concern (Beta, Gamma, Omicron). Position 501 in the S protein is within the receptor-binding motif (RBM) and is one of the six contact amino acid (a.a.) residues with ACE2. N501Y has been shown to improve the binding affinity of SARS-CoV-2 to ACE2 [9, ...
Background:SARS-CoV-2 VOCs, especially the Delta and Omicron variants, have been reported to show significant resistance to approved neutralizing monoclonal antibodies (mAbs) and vaccines. We previously identified a mAb named 35B5 that harbors broad neutralization to SARS-CoV-2 VOCs. Herein, we ex...
The recently emerged severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Beta (B.1.351) and Gamma (P.1) variants of concern (VoCs) include a key mutation (N501Y) found in the Alpha (B.1.1.7) variant that enhances affinity of the spike protein for its receptor, angiotensin-conver...
Fig. 1: Infection burden for illustrative variant of concern (VOC) scenarios, produced using the parsimonious SARS-CoV-2 transmission model. We considered three putative VOCs with differing transmissibility and immune-escape characteristics: more transmissible (VOC MT, blue line with square markers), ...