higher milk intake is associated with lower risk of T2D in lactase non-persistent (LNP) individuals (determined by a variant of the lactaseLCTgene, single nucleotide polymorphismrs4988235) but not in lactase persistent individuals. We validate this finding in the UK Biobank. Further analyses reveal...
Variant of the lactase LCT gene explains association between milk intake and incident type 2 diabetesEpidemiologyType 2 diabetesHigher milk intake is associated with lower type 2 diabetes risk in lactase non-persistent individuals, partly through gut microbiome and blood metabolites....
(2007). The T/G 13915 variant upstream of the lactase gene (LCT) is the founder allele of lactase persistence in an urban Saudi pop- ulation. J. Med. Genet. 44, e89.Imtiaz F, Savilahti E, Sarnesto A, Trabzuni D, Al-Kahtani K, Kagevi I, et al. The T/G 13915 variant ...
Lactase persistence (LP), the ability to maintain a high lactase activity throughout life, has been suggested to be a possible risk factor for diabetes. Recently, a single nucleotide polymorphism C (-13910) T, residing 14 kb from the 5' end of the lactase (LCT) gene was shown to be ...
- 2007 () Citation Context ...le correlated perfectly with the LP phenotype of intestinal cells and functional studies have shown that the T allele is associated with the disrupted down-regulation of the LCT gene during childhood =-=(2,3)-=-. The enhancer function of this mutation has ...
CONCLUSION: C/T -13910 cis-acting regulatory variant located approximately 14 kb upstream of lactase gene (LCT) completely correlates with lactase phenotype in Indian children. The genetic testing for the C/T -13910 variant may be helpful in the diagnosis of adult-type hypolactasia in Indian ...
More information:Kai Luo et al, Variant of the lactase LCT gene explains association between milk intake and incident type 2 diabetes,Nature Metabolism(2024).DOI: 10.1038/s42255-023-00961-1 Sheridan H. Littleton et al, Metabolic links among milk, genes and gut,Nature Metabolism(2024).DOI: 10...
Conclusion C/T − 13910 cis-acting regulatory variant located ≈ 14 kb upstream of lactase gene (LCT) completely correlates with lactase phenotype in Indian children. The genetic testing for the C/T − 13910 variant may be helpful in the diagnosis of adult-type hypolactasia in ...