Human Variant[edit] Just as the drow were elves driven below ground centuries ago and warped over the millennia by the dark forces they worshiped, it is speculated that dark folk were humans that came to be in the same way. But alas, this is only speculation; the race of dark folk are...
While ambitious humanoids seeking eternal youth, beauty, and adoration are common, those that go to the greatest lengths or are simply unlucky eventually find a being powerful and typically malicious enough to inflict the medusa curse. A gorgon may go several human lifetimes before ever meeting ano...
2f) and relative expression in several GBM cells and GSCs (Supplementary Fig. 2g). CircMET is a cytoplasm-localized circRNA (Supplementary Fig. 2f, i) and is more highly expressed in GSCs compared with NSCs and normal human astrocytes (NHAs) (Supplementary Fig. 2g). The expression of circ...
Mendelian randomization analysis using genetic variants, including rs1921622, demonstrated that decreased sST2 levels lower AD risk and related endophenotypes in females carrying the Apolipoprotein E (APOE)-ε4 genotype; the association is stronger in Chinese than in European-descent populations. Human ...
An urgent need for the study of human physiology and disease is the ability to efficiently introduce large numbers of specific single-base substitutions in endogenous loci in primary human cells.1 This ability would enable, in the context of natural regulation in disease-relevant cell types, a wi...
4a), suggesting that BQ.1.1 increased the binding affinity to human ACE2 during evolution from BA.5. To determine the responsible substitutions in the BQ.1.1 S protein that enhance ACE2 binding affinity, we prepared the RBDs of BA.2 and BA.5 S proteins that possess a BQ.1.1-specific ...
Deciphering which, if any, of the observed variants are causative of monogenic disease is challenging as each human genome has 5 million variants (compared to the reference human genome sequence). The new release of gnomAD v4.0 (http://gnomad.broadinstitute.org/) includes SNV data from 807,...
4a), suggesting that BQ.1.1 increased the binding affinity to human ACE2 during evolution from BA.5. To determine the responsible substitutions in the BQ.1.1 S protein that enhance ACE2 binding affinity, we prepared the RBDs of BA.2 and BA.5 S proteins that possess a BQ.1.1-specific ...
Oxidative damage to diverse physiological molecules, including proteins, lipids, and nucleic acids, is an inevitable outcome of various cellular activities in living organisms. In particular, some oxidised forms of nucleotides cause miscoding of genetic information, and have therefore been present as a ...
There will always be things that go bump in the night. And we, Witchers, are the ones who will bump back.A human stalks through the night, cat eyes shining in the darkened forest. All is silent save for the gentle tapping of his medallion against his chest. At the sound of an ...