www.nature.com/scientificreports OPEN received: 28 April 2016 accepted: 05 July 2016 Published: 27 July 2016 Increased dynamics in the 40–57 Ω-loop of the G41S variant of human cytochrome c promote its pro-apoptotic conformation Andreas Ioannis Karsisiotis1, Oliver M. Deacon1,...
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It also inspired the solution of the human BChE crystal structure [3]. The current manuscript is dedicated to Joel Sussman and Israel Silman in celebration of the 25th anniversary of the publication of the crystal structure of acetylcholinesterase. For decades it was assumed that BChE is ...
B), and (2) studied the heterogeneity of cfDNA variants and CTC overexpression signals in an hormone receptor positive/human epidermal growth factor receptor 2 negative (HR+/HER2−) MBC cohort. 2. Results 2.1. Patient Characteristics The cohort was specified to only consist of patients with ...
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Here we show that R1346H, but not T797M, is associated with lower hCaV3.3 protein levels, reduced glycosylation, and lower membrane surface levels of hCaV3.3 when expressed in human cell lines compared to wild-type. Consistent with our biochemical analyses, whole-cell hCaV3.3 currents in ...
Here we show that R1346H, but not T797M, is associated with lower hCaV3.3 protein levels, reduced glycosylation, and lower membrane surface levels of hCaV3.3 when expressed in human cell lines compared to wild-type. Consistent with our biochemical analyses, whole-cell hCaV3.3 currents in ...
In vivo amplification of the androgen receptor gene and progression of human prostate cancer. Nat. Genet. 1995, 9, 401–406. [CrossRef] [PubMed] 4. Koivisto, P.; Visakorpi, T.; Kallioniemi, O.P. Androgen receptor gene amplification: A novel molecular mechanism for endocrine therapy ...
Further analyses were performed using the UCSC Genome Browser (http://genome.ucsc.edu/, accessed on 24 July 2020) and associated links on the human GRCh38/hg38 genome assembly. Multiplex ligation-dependent probe amplification (MLPA) analysis (MRC Holland probemix P017) was performed according ...
Regulatory variants of human KITLG that affect hair color are located in a similar region to the CNV identified in dogs. Conservation tracks within the CNV are 86.1% identical to the human sequence. The human homologous region to the canine CNV is located 200 kb upstream of human KITLG. The...