此外,一些神经退行性疾病相关的蛋白,如帕金森病中的 α - 突触核蛋白(α -synuclein),会直接与 VAPB 结合,破坏 VAPB-PTPIP51 的相互作用和内质网 - 线粒体信号传导。在 FTD/ALS 中,突变的 TDP43、FUS、C9orf72 衍生的毒性二肽重复多肽(DPRs)和 Tau 等,会通过激活糖原合酶激酶 - 3β(GSK3β)来破坏 VA...
Conclusions Our findings suggest that the downregulation of VAPB-PTPIP51 expression after IS mediates structural damage to MAMs. This may exacerbate CIRI by inhibiting the PI3K pathway and activating autophagy, thus providing new therapeutic targets for IS....
Here, we show that the VAPB-PTPIP51 tethers regulate autophagy. We demonstrate that overexpression of VAPB or PTPIP51 to tighten ER-mitochondria contacts impairs, whereas small interfering RNA (siRNA)-mediated loss of VAPB or PTPIP51 to loosen contacts stimulates, autophagosome formation. Moreover...
The VAPB-PTPIP51 interaction is disrupted in Alzheimer's disease, Parkinson's disease, FTD and ALS. Here we review the roles of VAPB and PTPIP51 in ER-mitochondria signaling and the mechanisms by which neurodegenerative disease insults may disrupt the VAPB-PTPIP51 interaction.Blair, Kerry...
ALS/FTD- associated FUS activates GSK-3beta to disrupt the VAPB-PTPIP51 interaction and ER- mitochondria associations. EMBO Rep 17, 1326-42.Stoica, R.; Paillusson, S.; Gomez-Suaga, P.; Mitchell, J.C.; Lau, D.H.; Gray, E.H.; Sancho, R.M.; Vizcay-Barrena, G.; De Vos, K...
According to the CO-IP and MD results, phosphorylation at the serine 129 site of α-syn increased VAPB-PTPIP51 interactions, and α-syn interacted directly with PTPIP51. Furthermore, functional and pathway enrichment analyses revealed that the common interacting proteins of p-α-syn and VAPB ...
VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis. Human molecular genetics. 21:1299-1311.De Vos, K. J. et al. VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis. Hum. Mol. Genet. 21, 1299-1311 (2012)....
[F3–06–04]: THE VAPB‐PTPIP51 ER‐MITOCHONDRIA TETHERS IN FRONTOTEMPORAL DEMENTIA AND RELATED AMYOTROPHIC LATERAL SCLEROSISdoi:10.1016/j.jalz.2017.07.285Chris MillerKing's College LondonLondonUnited KingdomJohn Wiley & Sons, LtdAlzheimer's & Dementia...
THE VAPB-PTPIP51 ER-MITOCHONDRIA TETHERS IN FRONTOTEMPORAL DEMENTIA AND RELATED AMYOTROPHIC LATERAL SCLEROSISdoi:10.1016/j.jalz.2017.07.285Chris MillerAlzheimer's & Dementia
VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis. Hum Mol Genet. 2011.De Vos KJ, Morotz GM, Stoica R, Tudor EL, Lau KF, Ackerley S, Warley A, Shaw CE, Miller CC. VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis. ...