high blood creatinine (decreased kidney function). Serious side effects and warnings Valsartan can cause the following serious side effects. Harm or death to an unborn baby. Talk to your healthcare provider about other ways to lower your blood pressure if you plan to become pregnant. If you be...
Renal functionBackground: Sacubitril/valsartan is a foundational therapy for patients with heart failure (HF). Although current US FDA labeling does not identify threshold kidney function below which initiation or continuation of sacubitril/valsartan is precluded, guidelines generally identify eGFR<30mL...
This process utilizes kidney function to inhibit aldosterone-secreting effects that result in a decrease in vascular resistance and blood pressure. By inhibiting aldosterone secretion, the kidneys may also inhibit sodium and water reabsorption at the same time decreasing the excretion of potassium....
Kidney Function TestsTetrazolesUric AcidValine抗高血压药肾功能试验四唑类尿酸缬氨酸Journal of Human Hypertension is exclusively concerned with all clinical aspects of human hypertension. The journal publishes fully refereed original research papers from around the world....
and especially secondary hypertension caused by renal damage. It can significantly reduce proteinuria for hypertension patients with diabetes or normal liver functions, and it can promote uric acid and urinary sodium to protect the kidney. Valsartan is also suitable for reducing the cardiovascular mortali...
Patients whose renal function may depend in part on the activity of the renin-angiotensin system (e.g., patients with renal artery stenosis, chronic kidney disease, severe congestive heart failure, or volume depletion) may be at particular risk of developing acute renal failure on valsartan. ...
dilating blood vessels and lowering blood pressure, the effect is lasting and stable, and the toxic and side effects are small. Therefore, valsartan is mainly suitable for antihypertensive, mild to moderate primary hypertension, especially for the treatment of secondary hypertension caused by kidney ...
Adults with hypertension and diabetes mellitus, chronic kidney disease (CKD), or age ≥65 years are assumed to be at high risk for cardiovascular disease; ACC/AHA state that such patients should have antihypertensive drug therapy initiated at a BP ≥130/80 mm Hg....
However, it is important to note that dosage adjustment is not necessary for individuals with impaired kidney function, such as renal failure, or for those with non-biliary and non-cholestatic liver dysfunction. Additionally, Valsartan capsules can be used in combination with other antihypertensive ...
Noteworthy, HF is a well-known complication of chronic kidney disease (CKD), especially in end-stage kidney disease (ESKD), where dialysis patients are seven to eight times more likely to encounter cardiac arrest than the general population. Therefore, it is important to develop efficient ...