IV Valproate in generalized convulsive status epilepticus: a systematic review clinical trials randomized controlledclinical trials systematic review/meta-analysisStatus epilepticusvalproic acidAim of this review was to evaluate efficacy and ... F Brigo,M Storti,AD Felice,... - 《European Journal of Ne...
A method for the determination of the antiepileptic drug valproic acid and 14 of its metabolites in serum and urine by gas chromatography/mass spectrometry with selected ion monitoring of the trimethylsilylated derivatives has been developed. Sample preparation, including hydrolysis of VPA-conjugates and...
Patients were treated with escalating doses of decitabine (5–15 mg/m2) IV for 10 days in combination with VPA (10–20 mg/kg/day) PO on days 5–21 of a 28-day cycle. Pharmacokinetic and pharmacodynamic analysis included decitabine pharmacokinetics and fetal hemoglobin expression. ...
po: Per os PR: Partial remission QoL: Quality of life RARα: Retinoic acid receptor α sTRAIL: Soluble tumor necrosis factor-related apoptosis-inducing ligand UTX: Ubiquitously transcribed tetratricopeptide repeat, X chromosome VPA: Valproic acid WHO: World Health Organization.References...
Class II, III and IV HDACs contribute to tissue-specific function, formation of aggresome and autophagy, and cytokine regulation. However, each of these HDACs may have overlapped or their specific function in regulating various cellular activities, altering cell survival, apoptosis and epigenetic ...
VPA treatment may represent a new, interesting therapeutic approach to affect GSC proliferation and motility, but further investigations are certainly needed. Keywords: glioma stem cells; valproic acid; Wnt/β-catenin signalling pathway; cell proliferation; cell invasion Genes 2018, 9, 522; doi:...
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