A new study combines massively parallel assays, transcriptomics and biophysical modeling to provide a framework for analyzing the effects of compounds that modulate pre-mRNA splicing. The results lend important insights into the mechanisms of drug action and facilitate the design of splicing therapies. ...
View Research Foundation Paper Logic Model Scholastic R.E.A.L. View Research Independent Report Impact Study RISE & RISE Up End-of-Year Results View Research Impact Study Chesterfield RISE/RISE Up: How Students in South Carolina Significantly Improved Reading Achievement View Research Independent...
Future research should examine the temporal stability of the FS and the consequences of the positive skewness and limited external validity of the scale found in the current study. 展开 关键词: Mental well-being Social-psychological functioning Eudaimonic well-being Psychometric properties Confirmatory ...
Polygenic risk scores (PRSs) have improved in predictive performance, but several challenges remain to be addressed before PRSs can be implemented in the clinic, including reduced predictive performance of PRSs in diverse populations, and the interpretation and communication of genetic results to both ...
Fall rate prediction models were developed using a count regression modelling approach, and two of the three analyses have been published previously [17, 18]. In short, the results showed that the history of falls measured as the number of prior falls within 12 months before the study ...
To address this research gap, the aim of our study is to develop a robust nomogram capable of accurately predicting the risk of AKI in critically ill patients with acute pancreatitis admitted to the ICU. Methods Data The Medical Information Mart for Intensive Care(MIMIC) database is an ...
Results The Cronbach alpha coefficient (α=0.79),composite reliability value (ρ=0.81), andthe intraclass correlation coefficient(α=0.82)indicate the satisfactory reliability of the PAQ-C score.The CFA indicated data fit a single factor model, suggesting that the PAQ-C measures only one construct...
However, some problems were also found or reported in the clinical application of the QLICD (V1.0). For example, the structure of the scale was not completely reasonable, there was imprecision in reliability estimation and questions surrounding the validity of the test results. To solve these ...
Calibration, decision curve analysis (DCA), and receiver operating characteristic (ROC) measured the performance of the nomogram on the accuracy, clinical utility, and discrimination, respectively. Eventually, 368 ICU patients with TTS were enrolled in this research. The in-hospital mortality was ...
Published false positive research findings are a major problem in the process of scientific discovery. There is a high rate of lack of replication of results in clinical research in general, multiple sclerosis research being no exception. Our aim was to develop and implement a policy that reduces...