There are many methods to cross validation, we will start by looking at k-fold cross validation. K-Fold The training data used in the model is split, into k number of smaller sets, to be used to validate the model. The model is then trained on k-1 folds of training set. The remain...
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Materials and methods Patient population The Yonsei University Institutional Review Board approved this retrospective study and waived the need for obtaining informed patient consent. All methods were performed in accordance with the relevant guidelines and regulations. We identified 297 patients who were pa...
Functional studies of long noncoding RNAs (lncRNAs) have been hindered by the lack of methods to assess their evolution. Here we present lncRNA Homology Explorer (lncHOME), a computational pipeline that identifies a unique class of long noncoding RNAs (l
The methods for determining AFM1 can be classified into two main groups: chromatographic and immunochemical. Immunochemical methods are used for rapid screening of AFs in various sample matrices. Several approaches have been developed for the determination of AFM1, but the method of choice is ...
The Maximum Likelihood (ML) and Cross Validation (CV) methods for estimating covariance hyper-parameters are compared, in the context of Kriging with a misspecified covariance structure. A two-step approach is used. First, the case of the estimation of a single variance hyper-parameter is address...
Quantitative and qualitative procedures are necessary components of instrument development and assessment. However, validation studies conventionally emphasise quantitative assessments while neglecting qualitative procedures. Applying both methods in a m
Methods DNA-microarray experimental procedures DNA-microarrays were prepared from amplicons of 2108 genes in the genome ofLactococcus lactisssp.lactisIL1403 (Genbank accession number NC_002662; its annotation is based on theB. subtilisgenome, Genbank accession number NC_000964). Primers were designed...
2. Materials and methods 2.1. DNA and direct amplification substrates Control DNA 9948 was obtained from QIAGEN. Unless otherwise stated, the DNA from anonymous donor samples (blood, saliva, buccal swabs or mocked case-type samples, XX107 used for mixture study) was extracted by using the QIA...
Bushenhuoxue (BSHX) formula, a ten-compound herbal decoction, is widely used to treat postmenopausal osteoporosis (PMOP) in China. However, the mechanism is not clear yet. Methods The underlying biological processes and signaling pathways were predicted by network pharmacology. In vivo experimental...