When the mRNA COVID-19 vaccines were announced in December 2020 the world was excited that a vaccine was available to combat the coronavirus pandemic. One of the most frequent comments was a desire to wait because the vaccine technology was "so new." This articl...
mRNA Technology: Vaccines and Beyond Published on: June 28, 2023 We're using mRNA with the goal of developing new, life-saving vaccines and to address long-standing challenges in cancer, immune-mediated diseases, and rare diseases. 3D illustration of messenger RNA...
Using mRNA technology like that in the COVID-19 vaccines, researchers have demonstrated a successful way to deliver a potential HIV vaccine, researchers at Duke Human Vaccine Institute report. Publishing online March 15 in the journalCell Reports, the research team describes an important advancement ...
This new vaccine technology consists of a nanomedicine platform. You are basically getting mRNA and placing it in a nanoparticle, and you are using that to safely and effectively deliver the vaccine. This is my area of expertise—drug delivery. I work with various types of molecules but focus ...
Explore the innovative applications of mRNA technologies beyond COVID-19 vaccines. Learn about the potential and future developments in this groundbreaking field.
mRNA vaccines have elicited potent immunity against infectious disease targets in animal models of influenza virus, Zika virus, rabies virus and others, especially in recent years, using lipid-encapsulated or naked forms of sequence-optimized mRNA. Diverse approaches to mRNA cancer vaccines, including ...
The two vaccines, one from Pfizer/BioNTech and one from Moderna, were developed so rapidly by using the relatively unknown messenger RNA (mRNA) technology. So, how do mRNA vaccines work, and why are you suddenly hearing so much more about them? Unlike traditional vaccines, mRNA vaccines don...
mRNA vaccines have been revolutionary in terms of their rapid development and prevention of SARS-CoV-2 infections during the COVID-19 pandemic, and this technology has considerable potential for application to the treatment of cancer. Compared with traditional cancer vaccines based on proteins or pept...
The nature of mRNA technology allows rapid refinement with almost limitless combinations of derivatives in the pursuit of optimization. This necessitates the application of translational sciences to accelerate selection of the optimal construct and formulation for subsequent development. Clinical experience in...
Using combinations of multiple (e.g., 2–6) shared TAAs has become the trend in development of targeted mRNA cancer vaccines in the clinic. The selected TAAs are often widely expressed in related tumors and can induce antitumor immune responses when combined with different vectors or adjuvants....