Vaccination is an important and well-documented successful approach for disease prevention and public health intervention. The CDC estimates that for children in the USA who were born between 1994 and 2016, vaccination will prevent an estimated 381 milli
fellowship at Yale University School of Medicine, I no longer routinely admitted sick children with Hib meningitis. Over the course of just a few years, Hib meningitis had mostly disappeared in the United States because of the development, production, and distribution of a vaccine. This achievement...
Design strategies for Vesicular stomatitis virus (VSV), rabies virus (RABV), parainfluenza virus (PIV), measles virus (MeV), Newcastle disease virus (NDV), influenza virus (IFV), Adenovirus (AdV) and poxvirus for vaccine platforms.arVSVΔG/rRABVΔG, in which the glycoprotein (G) of the ...
as T-helper cells can have various effector functions. For instance, in the presence of cytokines, such as IL-12 and type I IFN, CD4+T-cells develop into T-helper 1 (Th1) cells. These cells produce cytokines, such as IFN-γ and tumor necrosis factor alfa (TNF-α), which potentiate ...
In response to the COVID-19 pandemic, 102 candidate vaccines on 10 platforms are in clinical development, and 15 vaccines have already been licensed or approved for emergency use [3]. These platforms can be classified either as trad- itional approaches that have previously resulted in li- cen...
© 2013 Landes Bioscience News, Policy & Profiles Human Vaccines & Immunotherapeutics: News Vaccinating boys against HPV to reduce cancer rates across the sexes In most countries, vaccines against human papilloma virus (HPV) are recommended only for girls in order to prevent cervical cancer caused...
HIV-1 envelope glycoproteins are poorly recognized by the immune system, which means that potent broadly neutralizing antibodies (bnAbs) are only infrequently induced in the setting of HIV-1 infection or through vaccination. Thus, the biology of HIV-1–host interactions necessitates novel strategies ...
Edible vaccines present exciting possibilities for significantly reducing various diseases such as measles, hepatitis B, cholera, diarrhea, etc., mainly in developing countries. However, various technical and regulatory challenges need to overcome in the path of this emerging vaccine technology to make ...
Over 200,000 new leprosy cases are reported globally every year. A vaccine for leprosy can eliminate the debilitating, biblical, and stigmatised disease in the twenty-first century. Since the 1940s, many clinical studies have consistently shown that the
Epidemics are sharply circumscribed, generally for 3 to 5 months. In family studies, children in early school years frequently introduce the virus into the home, infecting younger members of the family more severely than other family members. The clinical consequence of infection is most severe on...