In studying the question of specific therapeutics it is important to bear in mind, in the first place, the fundamental distinction between passive and active immunity. In the utilization of passive immunity in the cure of disease, aid to the individual comes from without. Moreover, the ...
21-4).298 Following unblinding of the study after 15 months of active observation, passive surveillance continued for 3 additional years, during which vaccine efficacy ranged from 77 to 92% for the bivalent vaccine and from 65 to 82% for the monovalent vaccine, depending on the case definition...
Passive immunotherapy for retroviral disease: influence of major histocompatibility complex type and T-cell responsiveness. Proc. Natl Acad. Sci. USA 92, 10492–10495 (1995) Article ADS CAS PubMed PubMed Central Google Scholar Kiepiela, P. et al. CD8+ T-cell responses to different HIV ...
Strategies targeting the viral receptor-binding domain to prevent receptor attachment may be a useful approach in passive immunity against other hemorrhagic fever viruses. The filovirus Ebola virus (EBOV) is probably a more difficult neutralizing antibody target than is JUNV; its receptor-binding subu...
Although combined passive and active immunoprophylaxis of infants has significantly reduced perinatal HBV infection, perinatal transmission occurs in up to 20% of infected mothers.59 To augment neonatal prophylactic strategies, the CDC ACIP recommends that pregnant women who are identified as being at ...
An individual can acquire immunity for a specific pathogen passively or actively. In passive immunization a person receives antibodies or lymphocytes that have been produced by another individual’s immune system; in active immunization the individual’s own immune system is stimulated to produce ...
Passive immunity is the administration of antibodies to an unimmunized person from an immune subject to provide temporary protection against a microbial agent or toxin. This type of immunity can be conferred on persons who are exposed to measles, mumps, whooping cough, polio, rabies, rubella (Ger...
Passive immunization may slow down SARS-CoV-2, boost immunity in patients, buy time for vaccine The convalescent plasma option for COVID-19 treatment. Credit: Lo’ai Alanagreh, PhD, the Hashemite University The convalescent plasma option for COVID-19 treatment. Credit: Lo’ai Alanagreh, PhD...
For these viruses, the protective efficacy of this passive immunization was 75% [60]. The importance of this should not be understated—the demonstration of passive humoral immunity as providing transmission protection, even without the concomitant induction of anti-HIV-1 CD8 T cell responses, was...
Moreover, disease progression after immunization was correlated to the titer of antibodies directed against an enhancing domain in both passive [41] and active immunization studies [42]. In other words, the higher the titer of antibody to primary enhancing domain the faster the animals proceeded ...