V-ATPase编码基因分为多个家族,包括ATP6V0、ATP6V1、ATP6V1A等。这些基因的突变或功能异常与一些疾病的发生和发展关系密切,如肾小管酸中毒、多囊肾等。对V-ATPase蛋白和其编码基因的研究有助于深入了解细胞内部调节机制以及相关疾病的发病机制,为治疗和预防相关疾病提供了新的思路和靶点。
此外,ATP6V0D1siRNA显著逆转了SolA诱导的BIM降解(图4B),表明ATP6V0D1通过调节BIM的稳定性而对神经元的存活负责。此外,我们观察到ATP6V0D1缺乏抑制了SolA介导的溶酶体pH降低的效应(图4C),支持ATP6V0D1通过促进溶酶体酸化依赖的线...
V-ATPase 伪1, also known as HO68, VA68, VPP2, Vma1 or ATP6V1A1, functions as the A subunit of the V1 domain. It is a 617 amino acid, ubiqui- tously expressed protein.van HilleRichenerEvansBilbe
To test whether loss of Atp6ap1b altered V-ATPase localization in other cell types, we analyzed enveloping layer (EVL) cells that lie on the surface of the embryo during epiboly stages and hair cells in neuromasts. Similar to DFCs, Atp6v1a puncta were found in EVL cells throughout the ...
基因别名:AI647066; ATP6A1; Atp6a2; ATP6V1A; ATP6V1A1; HO68; VA68; Vma1; VPP2 UniProt ID:(Human) P38606,(Mouse) P50516 Entrez Gene ID:(Human) 523,(Mouse) 11964,(Rat) 685232 功能 ATP bindingproton-transporting ATPase activity, rotational mechanismnucleotide bindinghydrolase activityhydrol...
1b). Interestingly, however, an interaction with the integral membranous V0 subunits ATP6V0a1 and ATP6v0d1 could not be detected (Fig. 1a). Before investigating the functional consequences of this interaction in the context of Ncoa7 disruption, we next measured the expression levels of a ...
(ab199326)Anti-ATP6V1A antibody [EPR19270] an Antibody byAbcam (ab40676)Anti-NAK/TBK1 antibody [EP611Y] an Antibody byAbcam (AP0946)Phospho-CGAS-Y215 Rabbit pAb an Antibody byABclonal (F3165)Monoclonal ANTI-FLAG® M2 antibody produced in mouse ...
d MET binds to the ATP6V1A subunit in the V-ATPase complex. Lysates from HepG2 cells were subjected to immunoprecipitation with antibodies against the subunits of V-ATPase or co-IgG. e The ratio of MET to each subunit of the V-ATPase complex that was immunoprecipitated is shown as ...
ATP6V1A通过AMPK促进PCK2抑制肾癌进展的机制研究 进而在肿瘤代谢重编程中起着"开关"作用.值得提及的是,v-ATPase及其各亚基亚型在多种实体恶性肿瘤中已被报道,但普遍认为其起到促进癌症发生,进展及肿瘤耐药等"促... 赵文磊 - 中国人民解放军医学院 被引量: 0发表: 2023年 ...
Association of a subunit with V-ATPase assembly chaperone, VMA21, and V1 marker, ATP6V1B1. HEK 293 cells were transfected with WT and mutant FLAG-tagged constructs. After 24 h expression, whole-cell lysates were immunoprecipitated with anti-FLAG antibody. A–C, immunoprecipitates were ...