V-ATPase编码基因分为多个家族,包括ATP6V0、ATP6V1、ATP6V1A等。这些基因的突变或功能异常与一些疾病的发生和发展关系密切,如肾小管酸中毒、多囊肾等。对V-ATPase蛋白和其编码基因的研究有助于深入了解细胞内部调节机制以及相关疾病的发病机制,为治疗和预防相关疾病提供了新的思路和靶点。
蛋白免疫印迹(wb)实验检测到4月龄app/ps1小鼠海马部位的atp6v1a、atp6v0a1表达水平降低。 11.3.本发明4月龄app/ps1小鼠在淀粉样斑块及学习记忆障碍出现之前,app/ps1小鼠已经出现了v-atpase变化。证实v-atpase可作为早期阿尔兹海默症的生物标志物。 12.4.本发明采用尿液检测是无创的,优于传统的脑脊液和血液检测。 附...
We report that V-ATPase is present in the olfactory epithelium, where we detected subunits ATP6V1A (the 70-kDa "A" subunit) and ATP6V1E2 (the 31-kDa "E" subunit) in olfactory sensory neurons, sustentacular cells, and Bowman's glands. We also located both isoforms of the 56-kDa B ...
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A synthetic peptide corresponding to a sequence within amino acids 500-600 of human ATP6V1A (NP_0016812) 查看免疫原 偶联物 Unconjugated 形式 Liquid 浓度 0.82 mg/mL 纯化类型 Affinity Chromatography 保存液 PBS, pH 7.3, with 50% glycerol 内含物 0.01% thimerosal 保存条件 -...
1与v-ATPase亚基Atp6v0d1具有相互作用,DDRGK1通过调控蛋白酶体降解途径来维持Atp6v0d1和Atp6v1a的正常表达,DDRGK1缺失则导致两者的异常积累,而v-ATPase亚基的... 曹言 - 南京农业大学 被引量: 0发表: 2022年 细菌效应蛋白揭示V-ATPase-ATG16L1通路介导异源自噬的研究 文章简介真核细胞通过选择性自噬的方式...
We have observed in HCT116 and SW480 colon cancer cell lines that TM9SF4 interacts with the ATP6V1H subunit of the V-ATPase V1 sector. Suppression of TM9SF4 with small interfering RNAs strongly reduces assembly of V-ATPase V0/V1 sectors, thus reversing tumor pH gradient with a decrease...
ATP6V1A siRNA, targeting the catalytic A subunit of V-ATPase, was used as a positive control and it is the only siRNA which decreases vesicle acidification of intracellular vesicles under steady-state conditions, although not as potently as Baf ((D), Control and Baf). After pretreatment with...
cells death by allosterically targeting ATP6V0d1 subunit of V-ATPase 【作者及发表单位】:本期推荐的是由北京大学药学院研究团队合作发布于Acta Pharmaceutica Sinica B(IF:14.903)的一篇文章,五味子醇A通过变构靶向V-ATPase亚基ATP6...
Briefly, a 1.38 kb region spanning exons 12–14 of the mouse a2V (gene name ATP6V0a2) was retrieved into a pLenti6 vector. A LoxP- FRP neo cassette was then introduced upstream of exon 12 along with restriction enzymes (SpeI and NsiI). Targeted embryonic stem cell clones with LoxP a2...