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synaptophysin, the presence of synaptophysin in synaptic vesicles profoundly affects the copy number of V-ATPases. This effect on the topography of synaptic vesicles suggests that synaptophysin assists in their biogenesis. In support of this model, we observed that synaptophysin-knockout mice exhibit ...
维恩妥尤单抗: 一种微管蛋白抑制剂、nectin-4抑制剂药物,由Astellas Pharma, Inc. (Astellas Pharma, Inc.)公司最早进行研发,目前全球最高研发状态为批准上市,作用机制: 微管蛋白抑制剂,nectin-4抑制剂(细胞黏附分子nectin-4抑制剂),治疗领域: 肿瘤,泌尿生殖系统疾病,消
Fig. 6: Characterization of acquired putative resistance alterations. a, Subgroups based on rate of acquiring resistance. Poisson mixture model was used to identify the low-, medium- and high-rate subgroups.b, Number of mutations grouped by SBS mutational signature at C1D1 and EoT.c, GSEA aga...
AXP365 Advanced Quality Management™ (LIMS)AX for Pharma Supply Chain Management+3 Complete LIMS for Microsoft Dynamics 365 to monitor, manage, and ensure product excellence. 28 out of 60 Business Process To-do Checklist for Dynamics 365 CRMInogic ...
Ligand-based virtual screening can be performed using the Atomic Property Field (APF) method developed by MolSoft ( Totrov 2008). APF is a 3D pharmacophoric potential implemented on a continuously distributed grid which can be used for ligand docking and scoring. APF can be generated from one...
Validation of the hV1-S1S4 identity To confirm the identity of purified hV1-S1S4, the SDS-PAGE band was cut and sent to the MS Bioworks, which performed liquid chromatography tandem mass spectrometry (LC-MS/MS). The result revealed that our purified hV1-S1S4 matches the hV1-S1S4 amino...
Illumina Illumina Forensic Genomic Validation Teach-Back 20011893 309000 Illumina Archer MBC Adapters A17-A24 SA0042 1600 Illumina ScriptSeq Complete Gold Kit (H/M/R) 24 reactions BG1224 停产,替代货号20020598、20020599 Illumina Illumina? Product Care NovaSeq? 6000 Basic Plan 20016094 1891000 ...
KAT is currently an employee of Astellas Pharma and has been an employee of AbbVie and may own stock or options. ECS has received compensation from Johns Hopkins University School of Medicine, National Institute on Drug Abuse (NIDA), Egalet, Indivior Pharmaceuticals, Jazz Pharmaceuticals, The Oak...
2.2 Test effort depending on the categorization The effort involved in validation (specification and testing) is much greater when using configured and, in particular, customized products compared to the effort for standard products (hardware and/or software). The overall effort for validation can ...