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SR141716A has been shown to enhance the contraction force of guinea pig ileum smooth muscle in isolated guinea pig ileum tests, but we found that it displayed a time-dependent decreasing trend, with the maximum effect at 30 s. The contraction fre- quency was increased 1.16 times by 10-5 ...
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(LAP). αvβ6-integrin activates TGFβ by binding to an RGD sequence of LAP, and by transmitting an actual pulling force, the protein complex is deformed and releases TGFβ [41,42]. Hence, the expression of αvβ6-integrin is tightly connected to diseases rooted in, or related to, ...
aTrial procedure in a two alternative force choice (2AFC) detection task. Monkeys fixated on a central red dot (0.2°) for at least 0.3 s to start a trial. After a variable blank period, a small (0.35°) target appeared for only 0.02 s on the right side or left side (eccent...
Renal tubule injury: a driving force toward chronic kidney disease 2018, Kidney International Citation Excerpt : TGF-β1 can induce cultured TECs to differentiate into cells with collagen-producing distinct myofibroblast morphology.70–72 Meanwhile, autocrine TGF-β signaling increases TEC production of ...
Myofibroblast differentiation is one main driving force of fibrosis48,49. These data suggest that Src inhibitor blocks the development of fibrotic lesions at least through inhibition of fibroblast migration, ECM protein production, and myofibroblast differentiation. Increased cell migration during fibrotic ...
A method of modifying the force of contraction of at least a portion of a heart chamber, including providing a subject having a heart, comprising at least a portion having an activa