Photostability, however, was affected by both the substitution positions and the types of substituents. An acid-catalyzed mechanism through enolization coupled with pre-organization viahydrogen bonding between two coumarin moieties is proposed as an explanation for the different extents of the [2+2] ...
Although clonal neo-antigen burden is associated with improved response to immune therapy, the functional basis for this remains unclear. Here we study this question in a novel controlled mouse melanoma model that enables us to explore the effects of intra-tumor heterogeneity (ITH) on tumor aggress...
1]. Skin is the body organ that is most exposed to UVR. Human skin is constantly exposed to potentially harmful compounds and radiation because it serves as a protective barrier between the environment and its internal organs, thus making it liable to aging [2]. Photoaging is a long-term p...
The subcellular distribution of AtCOP1 is adjusted according to light conditions (von Arnim and Deng, 1994; Yi and Deng, 2005). The huCOP1 ubiquitin ligase has been found to directly promote ubiquitin-dependent p53 degradation by the 26S proteasome. Similar to AtCOP1, mammalian COP1 (Yi ...
We confirmed that Ezh2 is regulated by miR-101 in human fibroblasts, and found that both overexpression of miR-101 and downregulation of Ezh2 independently induce senescence in the absence of UVB irradiation. However, the downregulation of miR-101 was not sufficient to block the phenotype of UVB...
In the third experiment a clear relationship between the duration of UVb exposure and the synthesis of vitamin D3and D2was found (Fig.3). Vitamin D2concentrations increased with prolonged UVb exposure within the chosen time frame (up to 64 hours over 8 days) whereas the vitamin D3concentra...
is very low, there is a possibility that Pom ellagitannin metabolites in the skin might alter the composition of the skin microbiota8. In addition, pigment forming bacteria can contribute to skin UV protection24. Therefore, it was our hypothesis that pomegranate consumption might alter the skin ...
We found that each of Gloeobacter's five psbA genes is expressed, with transcript abundances spanning 4.5 orders of magnitude. psbAI (glr2322) and psbAII (glr0779), encoding identical PsbA:2 form proteins, are constitutively expressed and dominate the psbA transcript pool under control conditions...
Because the species is tolerant to drought conditions, it is also found in xerophytic shrublands and eroded soil. This plant is distributed from northern Mexico to Guatemala at altitudes between 1500 and 3000 meters above sea level [9]. In Mexico, B. cordata is also known as “tepozan”,...
There was no difference between UVA and UVA 1 with respect to the nucleoid density time course. Hence, the initial absorbing chromophore is probably located in the UVA 1 region. In the case of PUVA, we found DNA repair that was complete after 12 h. The UVB part in the irradiation ...