The DL model based on MACCS + ECFP4 has the best performance, with evaluation metrics all above 88% and an AUC of 94.87%. Fig. 8 The evaluation metrics of DL models with group no. of VI (A), VII (B), VIII (C), IX (D), X (E) and XI–XV (F) on the test set (...
Nat. Biotechnol, 29 (2011), pp. 79-83 CrossrefGoogle Scholar 34. Shirasawa S., Furuse M., Yokoyama N., Sasazuki T. Altered growth of human colon cancer cell lines disrupted at activated Ki-ras Science, 260 (1993), pp. 85-88 CrossrefView in ScopusGoogle Scholar 35. Torrance C.J....
Consistent with the viability data, ST88-14 cells were more rapidly and strongly affected by Usp9X inhibition, than T265-2c cells. As with pharmacological inhibition of Usp9X activity, Usp9X knock-down pro- duced biochemical features of apoptotic cell death including a significant loss in ...
DUBs have been shown to participate in ubiquitin cleaving from ubiquitin conjugated protein substrates [29,30]. USP37, a novel DUB, contains an insert between its catalytic lobe and its ubiquitin-binding lobe while its function could prevent 14-3-3γ degradation, which might contribute to maligna...
[28,29,30]. Previous studies on CNS injury reported that exosomes of stem cells remarkedly promote functional recovery after SCI, brain injury and stroke in mice [13,17,27,31,32]. Moreover, exosomes exhibited protective effect in treatment of myocardial infarction, cardiomyopathy and ischemia-...
泛素特异性肽酶22(USP22)的抑制剂及其用于治疗疾病和病症的用途.pdf,本发明公开了治疗与泛素特异性肽酶22(USP22)的表达相关的疾病或病症的方法。所公开的方法可用于治疗与细胞增殖相关的疾病或病症,包括癌症。还公开了特异性抑制EC:3.4.19.12活性或由泛素的C端甘氨酸形成的
2 Convergence Medicine Research Center, Asan Institute for Life Sciences, Asan Medical Center, 88-gil, 43 Olympic-ro, Songpa-gu, Seoul 05505, Korea; nature8309@gmail.com (J.Y.); kimkyunggon@gmail.com (K.K.) * Correspondence: mjkang@amc.seoul.kr † These authors contributed equally to...
During spermatogenesis, deubiquitination enzymes play an important role in regulating diverse cellular activities and protein turnover (e.g., replacement of histones by protamine, germ cell apoptosis, mitotic proliferation, and differ- entiation of spermatogonial stem cells) [25–29]. Here, our ...
88 structural genes relating to the creation of B vitamins were detected. A comprehensive analysis incorporating B vitamin metabolism data and RNA sequencing data highlighted the pivotal transcription factors responsible for regulating thiamine and riboflavin accumulation in areca nuts, including AcbZIP21, ...
CORNING, N.Y.--(BUSINESS WIRE)--Jan. 29, 2025--Corning Incorporated(NYSE: GLW) today announced its fourth-quarter and full-year 2024 results and provided its outlook for first-quarter 2025. This press release features multimedia. View the full release here:https://www.businesswire.com/news...