1A). Expression of CSN1S1 across TCGA cancers (with tumor and normal samples) were observed using the UALCAN database (Fig. 1B). In the GENT2 database, gene expression was analyzed using the GPL570 HG-U133_Plus_2 platforms. The CSN1S1 transcription was down expressed in some specific...
For selecting a potent therapeutic target, the function and significance of the upregulated DEGs in TNBC was investigated by an in silico study employing the UALCAN portal, String database, KM plotter, and Enrichr tools. This analysis included gene expression validation, insights into protein-...
1A). The UALCAN platform revealed that PTGES3 protein levels were higher in HCC tissues than that in the adjacent tissues (Fig. 1B). Furthermore, Kaplan–Meier survival analysis revealed that patients with HCC overexpressing PTGES3 had a poor prognosis (Fig. 1C). Additionally, publicly ...
1A). The UALCAN platform revealed that PTGES3 protein levels were higher in HCC tissues than that in the adjacent tissues (Fig. 1B). Furthermore, Kaplan–Meier survival analysis revealed that patients with HCC overexpressing PTGES3 had a poor prognosis (Fig. 1C). Additionally, publicly ...
Additionally, the GEPIA database showed that the CDK1, CCNB1, CDC20, BUB1, MAD2L1, MCM3, BUB1B, MCM2, and RFC4 were associated with the poor survival of HCC patients. UALCAN, Oncomine, and HPA databases and qRT-PCR confirmed that these genes were highly expressed in HCC tissues. ...
21. Chandrashekar , Bashel B, Balasubramanya SAH, UALCAN: A portal for facilitating tumor subgroup gene expression and survival analyses: Neoplasia, 2017; 19; 649-58 22. Mok SC, Bonome T, Vathipadiekal V, A gene signature predictive for outcome in advanced ovarian cancer identifies a surviv...
ANK2 expression was analyzed using ONCOMINE, UALCAN, GEPIA2, and GENT2. Data from these servers showed the downregulated expression of ANK2 in BC relative to that in normal tissue. Further, downregulated ANK2 expression was found in such conditions as estrogen receptor-negative, human epidermal ...
We constructed protein-protein interaction (PPI) and DEM-hub gene networks using the STRING database and Cytoscape software. The GSE20189 dataset was used to screen out the key hub gene. Using The Cancer Genome Atlas (TCGA) and UALCAN databases to analyze the expression and prognosis of the ...
Finally, we selected colon and rectum adenocarcinoma of the TCGA dataset to perform expression and survival analysis for each 'hub' gene using UALCAN. Results: We identified a total of 163 up-regulated DEGs and 266 down-regulated DEGs in UC-CRC, among which 20 'hub' genes with a higher ...
The database STRING and Cytoscape were utilized to determine candidate hub genes. The hub genes were further investigated using UALCAN, Kaplan-Meier-plotter databases, Human Protein Atlas, and the AutoDock Vina software. The results of network pharmacology analysis were verified by in vit...