Imdusiran (AB-729) 和 IFN 的联合治疗总体上安全且耐受性良好。没有出现与Imdusiran (AB-729) 或 IFN 相关的严重不良事件 (SAE),也没有导致停药的不良事件 (AE)。 研究认为,Imdusiran (AB-729) 加 24W IFN 的耐受性良...
Fitusiran通过靶向抗凝血酶而平衡止血,由于其获益不受患者抑制物状态影响,覆盖的人群也更多,不仅是伴/不伴抑制物血友病A/B患者,甚至其他凝血因子缺乏的患者均可使用;并且Fitusiran注射频率非常低,每年仅需进行最低6次皮下注射,刚才吴...
Imdusiran (AB-729) 和 IFN 的联合治疗总体上安全且耐受性良好。没有出现与Imdusiran (AB-729) 或 IFN 相关的严重不良事件 (SAE),也没有导致停药的不良事件 (AE)。 研究认为,Imdusiran (AB-729) 加 24W IFN 的耐受性良好,迄今已有 4 例受试者达到功能性治愈,另有 1 例受试者在停止所有治疗 18W ...
2024年5月7日,赛诺菲Fitusiran注射液的上市申请获得NMPA受理,这也是Fitusiran的全球首报,有望实现中国率先上市。 Fitusiran为一款靶向抗凝血酶(AT)的siRNA疗法。 Fitusiran原本预计2022年递交上市申请,后因为安全性问题进行剂量调整,注册时间表也相应地有了延迟。 在A型或B型血友病中,凝血因子FVIII或FIX凝血酶的缺...
Imdusiran (AB-729) 是一种正在进行研究的 RNA干扰(RNAi)疗法,使用共价共轭N-乙酰半乳糖胺(GalNAc)递送技术,实现皮下递送,旨在降低所有HBV病毒蛋白和抗原,包括乙型肝炎表面抗原。聚乙二醇干扰素 alfa-2a (IFN) 是一种已获批准的 HBV 治疗药物,具有抗病毒和免疫调节作用。
Will the US pull out of Afghanistan because it’s losing the war? Or will it be a bargaining chip in the pending negotiation with Iran? I think both. Democrats have no stomach for war. They like to avoid conflict. They hope the confrontation will go away if it backs down. I believe ...
The pact does not constitute a military alliance, instead formalising the ties between Iran and Russia that have developed since the beginning of the war. Moscow is not in need of Iranian drones in the same way it was in 2022, following the development of its own domestic production c...
It was Iran’s first win in nine matches in the 2024 VNL. Eight of the world’s strongest men’s volleyball national teams - Brazil, Canada, France, Germany, Iran, Japan, the Netherlands and the US– have arrived in Manila, the Philippines. ...
"We have been slaughtered for over six months and no one dared to do anything. Now Iran, after its consulate was hit, is hitting back at Israel and this brings joy into our hearts," said Majed Abu Hamza of Gaza City. The war in Gaza, which Israel invaded aft...
The U.S. has a legal provision similar to the CAA which is known as the Specter Amendment that is tucked into the budget bill giving asylum to some non-Muslim minorities from Iran, while pointedly excluding Muslim. Asked by a Pakistani reporter if there was a double standard in Pompeo givi...