ursodeoxycholic acidTacrolimus (TAC) is a potent and well-tolerated immunosuppressive drug, but serious side effects including nephrotoxicity and hepatotoxicity have been reported. Ursodeoxycholic acid (UDCA) and resveratrol (RSV) exhibit hepatoprotective effects in liver diseases. We investigated the ...
Most of the drugs so far evaluated show some degree of efficacy but have major side effects. Given that ursodeoxycholic acid (UDCA) has no apparent toxicity in humans, it was postulated that long-term treatment with this drug might displace endogenous bile acids and thus reverse their suspected...
Ursodeoxycholic acid (UDCA) is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. UDCA is also a long-established drug, largely used for the ...
It is isomeric with Chenodeoxycholic acid, but less toxic than Chenodeoxycholic acid, less dosage. After oral administration, the product was rapidly absorbed; There were two peak plasma concentrations at th and 3H, respectively. Biological Half-Life of 3.5~3.8 days. UDCA in the liver with ...
Ursodeoxycholic acid (UDCA) is a secondary bile acid with cytoprotectant, immunomodulating, and choleretic effects. It reduces the cholesterol fraction of biliary lipids.1 UDCA inhibits the absorption of cholesterol in the intestine and the secretion of cholesterol into bile, decreasing biliary cholester...
12.2.1Ursodeoxycholic acid Ursodeoxycholic acid(UDCA), which is about 3% of thebile acidpool in humans, is extracted from the gallbladders of bears. Hepatoprotective effects have also been studied because of its worldwide use in the treatment ofprimary biliary cirrhosis. In a study of children ...
Ursodiol reduces cholesterol absorption and is used to dissolve gallstones.Target: OthersUrsodiol, also known as ursodeoxycholic acid and the abbreviation UDCA, is one of the secondary bile acids, which are metabolic byproducts of intestinal bacteria. The drug reduces cholesterol absorption and is used...
Celle, G.; Cavanna, M.; Bocchini, R.; Robbiano, L.; Dodero, M.; Volpi, C.; Dellepiane, F.; Cuneo-Crovari, P.; Scarvaglieri-Giuliano, R. and Sigari-Canu, G.: Chenodeoxycholic acid (CDCA)versusursodeoxycholic acid (UDCA): A comparison of their effects in pregnant rats. Archives...
Ursodeoxycholic acid in the treatment of primary biliary cirrhosis: A short-term, randomized, double-blind controlled, cross-over study with long-term foll... In order to evaluate the efficacy of ursodeoxycholic acid (UDCA) in the treatment of Chinese patients with primary biliary cirrhosis, a sh...
Ursodeoxycholic acid structure CAS No. 128-13-2 Chemical Name: Ursodeoxycholic acid Synonyms UDCA;URSODIOL;URSODESOXYCHOLIC ACID;Ursodeoxycholic;URSODEOXYCHOLATE;3-alpha,7-beta-dihydroxy-5-beta-cholanoicacid;Tauroursodiol;Urosodeoxycholic Acid;actigall;3-alpha,7-beta-dihydroxy-5-beta-cholan-24-oicaci...