By modification of the circulating pool of biliary acids, the administration of ursodesoxycholic acid has permitted the restoration of normal maternal hepatic function during a triple pregnancy complicated by the precocious onset of an intrahepatic cholestasis. The marked regression in clinical and ...
The optimal treatment of intrahepatic cholestasis of pregnancy (ICP)-a condition characterized by maternal pruritus that is associated with premature delivery, stillbirth and fetal distress-remains to be established. Ursodeoxycholic acid (UDCA) has been suggested as a treatment option for such patients;...
To test the efficacy and safety of ursodeoxycholic acid (UDCA) in the treatment of intrahepatic cholestasis of pregnancy (ICP) by a randomized, double-blind, placebo-controlled trial.Eight patients with pruritus and abnormal liver function tests received 600 mg/day of UDCA in two doses for 20 ...
( 2012 ). Efficacy of ursodeoxycholic acid in treating intrahepatic cholestasis of pregnancy: A meta-analysis . Gastroenterology , 143 , 1492 – 1501 .Bacq Y, Sentilhes L, Reyes HB, Glantz A, Kondrackiene J, Binder T, Nicastri PL, Locatelli A, Floreani A, Hernandez I et al (2012) ...
Ursodeoxycholic acid for adverse perinatal outcomes – Authors' reply The Lancet, Volume 395, Issue 10226, 7–13 March 2020, Pages 780-781 Lucy C Chappell, Catherine Williamson, Jim G Thornton Ursodeoxycholic acid versus placebo in women with intrahepatic cholestasis of pregnancy (PITCHES): a rando...
The second conception occurred in a period without the use of UDCA, implicating a latent beneficial effect of either UDCA orthe previous pregnancy via some possible immune mechanism. Conclusion(s) Ursodeoxycholic acid could help achieve conception in infertile women with primary biliary cirrhosis. The...
However, even now, there is no clear evidence as to whether the most popular treatment, a drug called ursodeoxycholic acid is beneficial to the baby, or even if it is safe in pregnancy. Nor do we know whether planned early delivery of the baby at 37–38 weeks, another popular ...
Ursodeoxycholic acid for the treatment of home parenteral nutrition-associated cholestasis: a case report. Gastroenterology 1991; 101: 250-3... KD Lindor - 《Gastroenterology》 被引量: 288发表: 1991年 Ursodeoxycholic acid for the treatment of intrahepatic cholestasis of pregnancy Objective : To report...
A randomised trial to evaluate both ursodeoxycholic acid and timed delivery is needed but will be complicated and expensive. We plan a preliminary study, Pilot study for a trial of ursodeoxycholic acid and/or early delivery for obstetric cholestasis (Acronym PITCH- Pregnancy Intervention Trial in ...
Ursodeoxycholic acid, a relatively hydrophilic bile acid, is also believed to protect the liver from the damaging effects of hydrophobicbile acids, which are retained in cholestatic disorders. Hydrophobic bile acids can be cytotoxic through detergent-like and nondetergent-like actions. The mechanisms re...