Uric acid is the metabolic end product of purine in human body. Hyperuric acid has harmful effects on many tissues and organs of human body. Excessive uric acid deposition in bones and joints can cause gout. Deposition in the kidney can cause kidney disease and renal failure. High uric acid...
Furthermore, different factors, such as uric acid, a natural antioxidant in the human body, and the patient's sex seem to influence cognitive and psychiatric manifestations, however their interplay remains to be better understood. The present study aimed to examine the interactions between motor ...
57,58 Uric acid is a small molecule that is present in the extracellular milieu at low concentration with no immunological effects. When it is released at high concentrations, it precipitates and forms insoluble crystals of monosodium urate (MSU), which are highly inflammatory. It has been very...
The blood uric acid level is the primary indicator of renal function in birds. An elevated uric acid level is a reliable indicator that renal function is impaired. With many tests, substantial elevations are necessary before there is reason for concern; however, even a subtle elevation in the ...
Serum uric acid (SUA) is the end product of purine and uric acid(UA) metabolism4, serving as both an indicator of renal function and an effective antioxidant in the human body5,6. SUA levels depend on the balance between dietary purine intake, xanthine oxidase activity, and renal excretion...
This cross-sectional study examines the association between serum uric acid levels and vascular dysfunction among individuals of sub-Saharan African
Uric acid production is involved in the synthesis of purines in the body and absorption of purines from the outside. In other words, purine is found in all human tissues and is also found in many foods. When cells die in the human body, purines are created. Uric acid is the end ...
Nakatochi, M. et al. Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals.Commun.Biol.2, 115 (2019). Google Scholar Cleophas, M. C. et al. ABCG2 polymorphisms in gout: insights into disease susceptibility and treatment approach...
Uric Acid–Associated Renal Disease Uric acidis the final degradation product ofpurine metabolismin humans. It is poorly soluble in plasma. Whenuric acidcauses symptoms and is deposited in tissues, the condition is known as gout. Outside the joints, the kidney is the major site of clinically ...
Side Effects ▪ Probenecid is well tolerated. ▪ Gastrointestinal irritationis usually mild. ▪ Allergic reactions usually are mild and occur in 2% to 4% of patients. Serious hypersensitivity is extremely rare. Important Notes ▪ Alcohol and high protein intake will increase uric acid levels ...