Researchers have developed 'urchin-like' ceria nanoparticles with inherent antioxidant properties that efficiently carry therapeutic microRNA, enabling gene therapy following intra-articular injection in a mouse model of osteoarthritis.doi:10.1038/s41584-023-01017-0Robert,Phillips...
CASGoogle Scholar Lu, X. Y.; Hao, G. P.; Sun, X. L.; Kaskel, S.; Schmidt, O. G. Highly dispersed metal and oxide nanoparticles on ultra-polar carbon as efficient cathode materials for Li-O2batteries.J. Mater. Chem. A2017,5, 6284–6291. CASGoogle Scholar Xu, S. M.; Liang, ...
Here, we first identify a type of microRNA-224-5p (miR-224-5p) from clinical samples of patients with OA that can protect articular cartilage from degeneration and further synthesize urchin-like ceria nanoparticles (NPs) that can load miR-224-5p for enhanced gene therapy of OA. Compared ...