基于UCSF标准，肝移植候选者人群的数量将增加5%~20%。此外，Mazzaferro教授等人在2009年提出的Up-to-Seven标准（最大肿瘤直径与肿瘤数目之和不超过7）目前也正在被一些临床中心采用，基于该标准接受肝移植治疗的患者5年生存率高达71%。降期治疗（即通过局部或全身性治疗以降低肿瘤负荷以达到米兰标准或扩展标准）是另一...
up-to-7标准up-to-7标准 研究目的及背景:肝细胞癌(Hepatocellular Carcinoma,HCC,以下简称肝癌)是最常见的消化道恶性肿瘤之一,在所有恶性肿瘤中其发病率及死亡率分别位居第5位和第3位,由于早期缺乏特异性症状体征,多数患者一旦诊断已属晚期,预后极差。据报道统计显示我国肝癌的发病人数就已经占了全球肝癌新发病例的...
通过甲胎蛋白水平的不同,对Up-to-seven标准进行了调整,包括以下3种情况: (a)如果甲胎蛋白水平<200ng/mL,则移植前肿瘤负荷(肿瘤数目与最大肿瘤直径之和)应符合Up-to-seven标准; b)如果甲胎蛋白水平在200-400ng/mL之间,则移植前肿瘤负荷应符合Up-to-five标准; c)如果甲胎蛋白水平在400-1000ng/mL之间,则...
The up-to-seven (Up-to-7) criteria [with 7 being the sum of the size and number of tumors for any given hepatocellular carcinoma (HCC)] have been recently proposed to identify potential candidates for liver transplantation (LT) among patients exceeding the Milan criteria. The aim of this ...
目的 建立并验证基于up-to-seven(Up7)标准肝细胞癌(HCC)肝移植术后患者的长期生存Cox回归预测模型,以辅助制定临床决策.方法 回顾性分析251例符合Up7标准的HCC肝移植术后患者的临床和随访资料.采用逐步回归向前法进行多因素Cox回归分析,获得HCC肝移植术后患者长期生存的独立预测因素,并建立长期生存Cox回归预测模型.使...
Liver transplantation is a controversial issue in the initial management of hepatocellular carcinoma (HCC). The aim of this study was to demonstrate that up-to-seven could be useful as a model in evaluating potential candidates for liver transplantation for HCC. METHODS: Between January 1997 and ...
据此,研究人员假设超出up-to-seven标准的中期HCC患者接受仑伐替尼初始治疗相比TACE能带来更好的预后。 基于仑伐替尼治疗高肿瘤负荷HCC具有高肿瘤缓解率 (40.2%) ,同时不损伤肝功能。 本研究旨在验证在肿瘤超出up-to-seven标准的HCC中期患者中,仑伐替尼初始治疗相比传统TACE (cTACE) 能否改善OS。 研究于2006年1...
This direct-to-billing claim includes precise E/M levels, CPT, ICD-10, HCC, HCPCS codes with appropriate modifiers and units. Both founders have PhDs in AI, significant ML and NLP experience, 60+ patents and publications, and a combined 20+ years of experience working at B2B companies and...
found that EZH2 inhibited the targeted regulation of miR-622 to upregulate CXCR4 and promote HCC tumorigenesis [13]. Moreover, several studies have reported that circRNA or lncRNA could sponge miR-622 and suppress its original function in different malignacies [12, 23], which prompted us to ...
to process patient charts directly from the EHR to create a direct-to-billing claim. This direct-to-billing claim includes precise E/M levels, CPT, ICD-10, HCC, HCPCS codes with appropriate modifiers and units. Both founders have PhDs in AI, significant ML and NLP experience, 60+ patents...